{"title":"A critical analysis of stress-related gene regulation in isolated and connected individuals","authors":"","doi":"10.1016/j.bbi.2024.09.035","DOIUrl":null,"url":null,"abstract":"<div><div>This letter responds to the article by Yvonne S. Yang et al. (2024) on the relationship between social isolation, loneliness, and stress-related gene expression, published in Brain, Behavior, and Immunity. The authors’ recruitment methods and use of genome-wide transcriptional profiling to assess the Conserved Transcriptional Response to Adversity (CTRA) are highly commendable, offering a comprehensive understanding of how social isolation impacts immune gene expression. However, we raise concerns about the small sample size, demographic limitations, cross-sectional design, and lack of correction for multiple comparisons, which may affect the study’s generalizability and validity. Despite these limitations, the study provides valuable insights, paving the way for future research to explore the complex interactions between social isolation, loneliness, and health. We recommend that future studies address these limitations to enhance the robustness of findings and the development of effective interventions.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain, Behavior, and Immunity","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S088915912400638X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This letter responds to the article by Yvonne S. Yang et al. (2024) on the relationship between social isolation, loneliness, and stress-related gene expression, published in Brain, Behavior, and Immunity. The authors’ recruitment methods and use of genome-wide transcriptional profiling to assess the Conserved Transcriptional Response to Adversity (CTRA) are highly commendable, offering a comprehensive understanding of how social isolation impacts immune gene expression. However, we raise concerns about the small sample size, demographic limitations, cross-sectional design, and lack of correction for multiple comparisons, which may affect the study’s generalizability and validity. Despite these limitations, the study provides valuable insights, paving the way for future research to explore the complex interactions between social isolation, loneliness, and health. We recommend that future studies address these limitations to enhance the robustness of findings and the development of effective interventions.
这封信是对Yvonne S. Yang等人(2024年)发表在《脑、行为与免疫》(Brain, Behavior, and Immunity)杂志上的一篇关于社会隔离、孤独感和压力相关基因表达之间关系的文章的回应。作者的招募方法和使用全基因组转录谱分析来评估对逆境的保守转录反应(CTRA)的做法非常值得称赞,这为我们全面了解社会隔离如何影响免疫基因表达提供了依据。然而,我们对样本量小、人口统计学限制、横断面设计以及缺乏多重比较校正等问题表示担忧,因为这些问题可能会影响研究的推广性和有效性。尽管存在这些局限性,但这项研究提供了宝贵的见解,为今后研究探索社会隔离、孤独感和健康之间复杂的相互作用铺平了道路。我们建议未来的研究解决这些局限性,以提高研究结果的稳健性和有效干预措施的开发。
期刊介绍:
Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals.
As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.