Variability of macrolide-resistant profile in Mycobacterium avium complex pulmonary disease.

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2024-11-06 Epub Date: 2024-10-08 DOI:10.1128/aac.01213-24

Kiyoharu Fukushima, Yuki Matsumoto, Yuko Abe, Kazuki Hashimoto, Daisuke Motooka, Seigo Kitada, Haruko Saito, Sho Komukai, Eriko Fukui, Takayuki Niitsu, Hiroshi Nabeshima, Yasuharu Nagahama, June Yamauchi, Tadayoshi Nitta, Takuro Nii, Takanori Matsuki, Kazuyuki Tsujino, Keisuke Miki, Yasushi Shintani, Atsushi Kumanogoh, Shizuo Akira, Shota Nakamura, Hiroshi Kida

引用次数: 0

Abstract

This single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with Mycobacterium avium complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).

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复合分枝杆菌肺病中耐受大环内酯类药物情况的变异性。

这项单中心回顾性研究旨在分析68名复合分枝杆菌肺病患者对大环内酯类药物耐药性（MR）的变化情况。在未使用大环内酯类药物治疗的 25 名患者中，有 13 人（52%）恢复了对大环内酯类药物的耐药性（MR）。在继续接受大环内酯类药物治疗的 43 名患者中，只有 1 人（2%）出现了这种变化。我们将 30 例 MR 分离物与近期标本进行了比较。其中，7 例转为 MS 型（5 例为克隆相关菌株；2 例为再感染或多克隆感染所致）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.