The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals.

IF 4.6 2区医学 Q1 MICROBIOLOGY

Annals of Clinical Microbiology and Antimicrobials Pub Date : 2024-10-09 DOI:10.1186/s12941-024-00740-0

Janane Nasr, Hilal Abdessamad, Johnathan Mina, Tony Haykal, Yasser Jamil, Emma Abboud, Ahmad Mahdi, Rana Asmar, Rawad Abi Assaad, Dana Alameddine, Alaa Bourji, Mahmoud Mahdi, Razan Abdulaal, Serge Tomassian, Hanane El Ahmadieh, Wael Azzam, Jacques E Mokhbat, Rima Moghnieh, Alfonso J Rodriguez-Morales, Rola Husni

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Abstract

Introduction: Gram-negative bacteremia is a life-threatening infection with high morbidity and mortality. Its incidence is rising worldwide, and treatment has become more challenging due to emerging bacterial resistance. Little data is available on the burden and outcome of such infections in Lebanon.

Methods: We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020.

Results: Most bacteremias were caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes.

Conclusion: This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon.

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黎巴嫩革兰氏阴性菌血症的流行病学：对四家医院的研究。

导言：革兰氏阴性菌血症是一种危及生命的感染，发病率和死亡率都很高。其发病率在全球范围内不断上升，由于新出现的细菌耐药性，治疗变得更具挑战性。有关黎巴嫩此类感染的负担和结果的数据很少：我们在四家黎巴嫩医院进行了这项回顾性研究。方法：我们在黎巴嫩四家医院开展了这项回顾性研究，收集了 2014 年 1 月至 2020 年 12 月期间根据血液培养阳性诊断为血流感染的 2400 名患者的医疗条件和人口统计学数据：结果：大多数菌血症由大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌引起，耐药菌多为医院获得。在整个研究过程中，第三代头孢菌素和喹诺酮类药物的耐药性保持稳定，但碳青霉烯类耐药性有所增加。此类感染的死亡率很高，但碳青霉烯类耐药或感染假单胞菌或醋酸杆菌是导致不良后果的重要风险因素：这是黎巴嫩首次就革兰氏阴性菌血症、耐药模式和不良预后相关因素开展多中心研究。黎巴嫩需要更多的监测数据来指导菌血症的经验性治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Microbiology and Antimicrobials MICROBIOLOGY-

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of Clinical Microbiology and Antimicrobials considers good quality, novel and international research of more than regional relevance. Research must include epidemiological and/or clinical information about isolates, and the journal covers the clinical microbiology of bacteria, viruses and fungi, as well as antimicrobial treatment of infectious diseases. Annals of Clinical Microbiology and Antimicrobials is an open access, peer-reviewed journal focusing on information concerning clinical microbiology, infectious diseases and antimicrobials. The management of infectious disease is dependent on correct diagnosis and appropriate antimicrobial treatment, and with this in mind, the journal aims to improve the communication between laboratory and clinical science in the field of clinical microbiology and antimicrobial treatment. Furthermore, the journal has no restrictions on space or access; this ensures that the journal can reach the widest possible audience.