Relationship of high-density lipoprotein subfractions and apolipoprotein A-I with fat in the pancreas.

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2024-10-08 DOI:10.1111/dom.15990

Yutong Liu, Xiatiguli Shamaitijiang, Loren Skudder-Hill, Wandia Kimita, Ivana R Sequeira-Bisson, Maxim S Petrov

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引用次数: 0

Abstract

Aim: To investigate the associations of high-density lipoprotein (HDL) subfractions and apolipoprotein A-I (apo A-I) with fat in the pancreas.

Methods: A total of 170 individuals were studied. All participants underwent magnetic resonance imaging on a single 3.0-Tesla scanner to determine the presence/absence of fatty pancreas. HDL subfractions were measured using a commercially available lipoprotein subfractions testing system and classed as large, intermediate and small HDL. Both unadjusted and adjusted (accounting for demographics, anthropometrics, insulin resistance and other covariates) logistic regression models were built.

Results: Individuals with fatty pancreas had significantly lower circulating levels of the large HDL class and apo A-I. Every unit decrease in the large HDL class was associated with a 93% increase in the likelihood of fatty pancreas in the most adjusted model (P < .001). Every unit decrease in apo A-I was associated with a 45% increase in the likelihood of fatty pancreas in the most adjusted model (P = .012). The intermediate and small HDL classes were not significantly associated with fatty pancreas.

Conclusions: Fat in the pancreas is inversely associated with the circulating levels of large HDL particles and apo A-I. Purposely designed studies are warranted to investigate the potential of fatty pancreas as an indicator of the risk of cardiovascular diseases.

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高密度脂蛋白亚组分和载脂蛋白 A-I 与胰腺脂肪的关系。

目的：研究高密度脂蛋白（HDL）亚组分和载脂蛋白A-I（apo A-I）与胰腺脂肪的关系：方法：共对 170 人进行了研究。所有参与者都在一台 3.0 特斯拉扫描仪上进行了磁共振成像，以确定是否存在脂肪胰腺。使用市售的脂蛋白亚组分测试系统测量高密度脂蛋白亚组分，并将其分为大型、中型和小型高密度脂蛋白。建立了未调整和调整（考虑人口统计学、人体测量学、胰岛素抵抗和其他协变量）逻辑回归模型：结果：脂肪胰腺患者循环中的大高密度脂蛋白和载脂蛋白 A-I 水平明显较低。在调整程度最高的模型中，大高密度脂蛋白水平每降低一个单位，患脂肪胰腺的可能性就会增加 93%（P 结论：脂肪胰腺与高密度脂蛋白水平有关：胰腺中的脂肪与大高密度脂蛋白颗粒和载脂蛋白 A-I 的循环水平成反比。有必要进行专门设计的研究，以调查脂肪胰腺作为心血管疾病风险指标的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.