The effect of swimming and running exercises on oxidant-antioxidant and lipid profiles in streptozotocin-induced diabetic rats.

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Hippokratia Pub Date : 2023-10-01

M Bahar, N Demirci, L Bahar, L Şahin

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引用次数: 0

Abstract

Background: Lifestyle changes in Diabetes Mellitus (DM) positively affect blood glucose and all risk factors. This study aims to determine the effect of swimming and running exercises on oxidant-antioxidant and lipid profiles in streptozotocin (STZ)-induced type 1 diabetic and non-diabetic rats.

Methods: We included forty-eight adult male Wistar albino rats in this study, and we randomly classified them into six groups (eight per group). The groups were organized as Control Sedentary, Control Exercise-swimming, Control Exercise-running (CE-r), Diabetes Sedentary (DS), Diabetes Exercise-swimming (DE-s), and Diabetes Exercise running (DE-r). Half of these rats were subjected to experimental diabetes via STZ. We evaluated total oxidant capacity (TOC), total antioxidant capacity (TAC), superoxide dismutase (SOD), and as lipid parameters: high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. The rats were sacrificed at the end of the four weeks.

Results: We found a significant difference between DE-s and DE-r groups in terms of TOC (p =0.043) and SOD (p =0.030). The highest TAC was found in the CE-r group, and the highest TOC was found in the DS group. Exercise significantly reduced LDL levels. There was no significant difference between the DE-s and DE-r groups (p =0.084) for lipid profiles (HDL).

Conclusion: Based on the lower TOC (oxidant) and higher SOD (antioxidant) levels in the diabetic running group, these results suggest that running may be more beneficial than swimming for diabetics. HIPPOKRATIA 2023, 27 (4):148-154.

本刊更多论文

游泳和跑步运动对链脲佐菌素诱导的糖尿病大鼠体内氧化抗氧化物和血脂的影响

背景：糖尿病（DM）患者改变生活方式会对血糖和所有危险因素产生积极影响。本研究旨在确定游泳和跑步运动对链脲佐菌素（STZ）诱导的 1 型糖尿病大鼠和非糖尿病大鼠体内氧化抗氧化物和血脂的影响：将 48 只成年雄性 Wistar 白化大鼠随机分为 6 组（每组 8 只）。各组分别为静坐对照组、游泳运动对照组、跑步运动对照组（CE-r）、静坐糖尿病组（DS）、游泳运动糖尿病组（DE-s）和跑步运动糖尿病组（DE-r）。这些大鼠中有一半通过 STZ 患上了实验性糖尿病。我们评估了大鼠的总氧化能力（TOC）、总抗氧化能力（TAC）、超氧化物歧化酶（SOD）以及血脂指标：高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和甘油三酯。大鼠在四周结束时被处死：我们发现，DE-s 组和 DE-r 组的总有机碳（P =0.043）和 SOD（P =0.030）有明显差异。CE-r组的TAC最高，DS组的TOC最高。运动能明显降低低密度脂蛋白水平。DE-s 组和 DE-r 组在血脂（高密度脂蛋白）方面没有明显差异（p =0.084）：结论：根据糖尿病跑步组较低的 TOC（氧化剂）和较高的 SOD（抗氧化剂）水平，这些结果表明，对于糖尿病患者来说，跑步可能比游泳更有益。Hippokratia 2023，27 (4)：148-154。

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来源期刊

Hippokratia MEDICINE, GENERAL & INTERNAL-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hippokratia journal is a quarterly issued, open access, peer reviewed, general medical journal, published in Thessaloniki, Greece. It is a forum for all medical specialties. The journal is published continuously since 1997, its official language is English and all submitted manuscripts undergo peer review by two independent reviewers, assigned by the Editor (double blinded review process). Hippokratia journal is managed by its Editorial Board and has an International Advisory Committee and over 500 expert Reviewers covering all medical specialties and additionally Technical Reviewers, Statisticians, Image processing Experts and a journal Secretary. The Society “Friends of Hippokratia Journal” has the financial management of both the printed and electronic edition of the journal.