Investigation for statin intolerance reveals possible Charcot-Marie-Tooth disease in a coronary patient: A case report.

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Hippokratia Pub Date : 2023-10-01

M Sotiriadou, M Manani, E Kouzoukidou, E Oikonomidou

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引用次数: 0

Abstract

Background: Statin regimens are essential for managing lipids and preventing cardiovascular diseases, both in primary and secondary prevention, alongside lifestyle changes. There are, however, some side-effects associated with statin intake, such as an elevation of (CK) and myopathy.

Case description: This case describes a coronary patient with high low-density lipoprotein cholesterol (LDL-C) who was undertreated due to elevated creatine kinase (CK) levels and myopathy initially linked to statin use. A proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) replaced statin therapy; however, the existence of persisting/recurrent symptoms or CK elevation posed the need for further investigation. A neurological examination, an electromyography (EMG), and a nerve conduction study (NCV) revealed an underlying sensorimotor polyneuropathy, probably Charcot-Marie-Tooth disease.

Conclusions: Persistent muscle symptoms in patients receiving statins should not be always attributed solely to statin intake. Further neurological evaluation could reveal underlying hereditary sensorimotor polyneuropathies. PCSK9i could serve as the therapy of choice in such cases, as additional drug-induced myopathy could pose severe problems for those patients. HIPPOKRATIA 2023, 27 (4):155-157.

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他汀类药物不耐受的调查发现一名冠心病患者可能患有夏科-玛丽-牙病：病例报告。

背景：他汀类药物是控制血脂和预防心血管疾病的重要药物，无论是一级预防还是二级预防，同时改变生活方式也很重要。然而，服用他汀类药物也会产生一些副作用，如肌酸激酶（CK）升高和肌病：本病例描述的是一名冠心病患者，其低密度脂蛋白胆固醇（LDL-C）较高，由于肌酸激酶（CK）水平升高和肌病最初与他汀类药物的使用有关，因此治疗不足。他汀类药物治疗被丙型转化酶枯草酶/kexin9型抑制剂（PCSK9i）所取代；但是，持续/反复出现的症状或肌酸激酶升高表明有必要进行进一步检查。神经系统检查、肌电图（EMG）和神经传导研究（NCV）发现了潜在的感觉运动性多发性神经病，可能是Charcot-Marie-Tooth病：结论：接受他汀类药物治疗的患者出现持续性肌肉症状，不应仅仅归因于他汀类药物的摄入。进一步的神经学评估可能会发现潜在的遗传性感觉运动多发性神经病。PCSK9i 可作为此类病例的首选疗法，因为药物诱发的其他肌病可能会给这些患者带来严重问题。Hippokratia 2023，27 (4)：155-157。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hippokratia MEDICINE, GENERAL & INTERNAL-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hippokratia journal is a quarterly issued, open access, peer reviewed, general medical journal, published in Thessaloniki, Greece. It is a forum for all medical specialties. The journal is published continuously since 1997, its official language is English and all submitted manuscripts undergo peer review by two independent reviewers, assigned by the Editor (double blinded review process). Hippokratia journal is managed by its Editorial Board and has an International Advisory Committee and over 500 expert Reviewers covering all medical specialties and additionally Technical Reviewers, Statisticians, Image processing Experts and a journal Secretary. The Society “Friends of Hippokratia Journal” has the financial management of both the printed and electronic edition of the journal.