Enhanced patient journey associated with improved overall survival in colon cancer patients: A study by the Ligurian Oncology Network.

IF 2 4区医学 Q3 ONCOLOGY

Tumori Pub Date : 2024-12-01 Epub Date: 2024-10-06 DOI:10.1177/03008916241286692

Andrea Boutros, Nidia Sofia Diaz Gaitan, Giovanni Orengo, Eva Blondeaux, Alessandro Pastorino, Monica Zacconi, Francesca Ferrè, Luca Boni, Barbara Cardinali, Lucia Del Mastro

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引用次数: 0

Abstract

Background: Colon cancer imposes a significant burden on global healthcare systems, necessitating efforts to improve oncology care quality and patient outcomes. We studied the correlation between care quality and survival outcomes among colon cancer patients within the Ligurian Oncology Network (Italy).

Methods: We developed an Overall Quality Score (OQS) to evaluate the impact of oncology care quality on survival outcomes within the Ligurian Oncology Network. OQS indicators were selected through expert consensus, covering screening, diagnosis, treatment, and follow-up. A sample of colon cancer patients diagnosed in 2012 was randomly selected from administrative healthcare data. Analyses were performed using two models: a binary model (High and Low OQS) and a stratified model (Low, Medium, and High OQS). Statistical analysis involved survival curves, log-rank tests, and Cox proportional hazards models using SAS 9.4.

Results: Of 175 eligible colon cancer patients, 150 were included. Following a median follow-up of 7.6 years, a correlation between High-OQS (⩾ 65%) and prolonged disease-free survival was observed (unadjusted HR 0.57, 95%CI 0.33-0.99, log-rank p=0.041). The five-year disease-free survival rate for High-OQS patients was 70% (95%CI 57-80%), compared to 53% (95%CI 41-64%) for Low-OQS patients. Similarly, the five-year overall survival rate was 78% (95%CI 65-86%) for High-OQS patients, compared to 58% (95%CI 45-68%) for Low-OQS patients (unadjusted HR 0.56, 95%CI 0.31-1.00, log-rank p=0.048).

Conclusions: Our findings highlight the potential impact of the patient journey on colon cancer survival outcomes. Optimising care pathways might improve patient outcomes in colon cancer management.

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患者旅程的改善与结肠癌患者总生存率的提高有关：利古里亚肿瘤网络的一项研究。

背景：结肠癌给全球医疗系统带来了沉重负担，因此必须努力提高肿瘤治疗质量和患者预后。我们研究了利古里亚肿瘤网络（意大利）内结肠癌患者的治疗质量与生存结果之间的相关性：我们制定了综合质量评分（OQS），以评估利古里亚肿瘤网络内肿瘤治疗质量对生存结果的影响。OQS 指标是通过专家共识选定的，涵盖筛查、诊断、治疗和随访。从行政医疗数据中随机抽取了2012年确诊的结肠癌患者样本。分析采用两种模型：二元模型（高和低 OQS）和分层模型（低、中和高 OQS）。统计分析包括生存曲线、对数秩检验和使用 SAS 9.4 的 Cox 比例危险模型：在 175 名符合条件的结肠癌患者中，有 150 人被纳入研究。中位随访 7.6 年后，观察到高 OQS（⩾ 65%）与无病生存期延长之间存在相关性（未调整 HR 0.57，95%CI 0.33-0.99，log-rank p=0.041）。高OQS患者的五年无病生存率为70%（95%CI 57-80%），而低OQS患者为53%（95%CI 41-64%）。同样，高OQS患者的五年总生存率为78%（95%CI 65-86%），而低OQS患者为58%（95%CI 45-68%）（未调整HR 0.56，95%CI 0.31-1.00，log-rank p=0.048）：我们的研究结果凸显了患者治疗过程对结肠癌生存结果的潜在影响。优化护理路径可改善结肠癌患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tumori 医学-肿瘤学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Tumori Journal covers all aspects of cancer science and clinical practice with a strong focus on prevention, translational medicine and clinically relevant reports. We invite the publication of randomized trials and reports on large, consecutive patient series that investigate the real impact of new techniques, drugs and devices inday-to-day clinical practice.