Dexamethasone versus 5-HT3 receptor antagonists in preventing nausea during awake craniotomy: a propensity score matching study.

IF 0.8 Q3 ANESTHESIOLOGY

JA Clinical Reports Pub Date : 2024-10-07 DOI:10.1186/s40981-024-00746-9

Takehito Sato

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引用次数: 0

Abstract

Background: Nausea and vomiting during awake craniotomy (AC) can increase cerebral pressure and cause asphyxia and aspiration. 5-HT3 receptor antagonists, such as granisetron, are often administered before awakening to prevent nausea during AC. Recently, dexamethasone was reported to prevent nausea and vomiting during AC; however, the efficacy of both drugs in preventing nausea has not yet been investigated.

Methods: We examined the frequency of nausea and vomiting in AC patients (n = 170) treated at our hospital until the end of September 2019. We divided patients as those who received dexamethasone (n = 71) and or granisetron (n = 99) before awakening and examined the frequency of nausea and vomiting after propensity score (PS) matching.

Result: Eighty-two patients were selected after PS matching. The incidence of nausea was significantly lower in the dexamethasone group than in the granisetron group (9.8% vs 41.5%, p = 0.002). In the logistic regression analysis after matching, the incidence of nausea significantly reduced with dexamethasone treatment (odds ratio: 0.12, 95% confidence interval: 0.029-0.499, p = 0.03).

Conclusion: In conclusion, dexamethasone was more effective than granisetron in preventing nausea during AC.

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地塞米松与 5-HT3 受体拮抗剂在预防清醒开颅手术中的恶心作用：倾向得分匹配研究。

背景：清醒开颅手术（AC）期间的恶心和呕吐会增加脑压，导致窒息和吸入。苏醒前通常使用 5-HT3 受体拮抗剂（如格拉司琼）来预防开颅手术中的恶心。最近，有报道称地塞米松可预防交流过程中的恶心和呕吐；然而，这两种药物在预防恶心方面的疗效尚未得到研究：我们研究了截至 2019 年 9 月底在我院接受治疗的 AC 患者（n = 170）的恶心和呕吐频率。我们将患者分为苏醒前接受地塞米松（n = 71）和或格拉司琼（n = 99）的患者，并在倾向评分（PS）匹配后检查了恶心和呕吐的频率：结果：经过倾向评分（PS）匹配后，选出了82名患者。地塞米松组的恶心发生率明显低于格拉司琼组（9.8% vs 41.5%，P = 0.002）。在匹配后的逻辑回归分析中，地塞米松治疗后恶心的发生率明显降低（几率比：0.12，95% 置信区间：0.029-0.499，P = 0.03）：总之，地塞米松比格列奈司琼更能有效预防交流过程中的恶心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JA Clinical Reports ANESTHESIOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： JA Clinical Reports is a companion journal to the Journal of Anesthesia (JA), the official journal of the Japanese Society of Anesthesiologists (JSA). This journal is an open access, peer-reviewed, online journal related to clinical anesthesia practices such as anesthesia management, pain management and intensive care. Case reports are very important articles from the viewpoint of education and the cultivation of scientific thinking in the field of anesthesia. However, submissions of anesthesia research and clinical reports from Japan are notably decreasing in major anesthesia journals. Therefore, the JSA has decided to launch a new journal, JA Clinical Reports, to encourage JSA members, particularly junior Japanese anesthesiologists, to publish papers in English language.