The impact of different degrees of stenosis on platelet deposition in the left anterior descending branch of the coronary artery

IF 4.9 2区医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer methods and programs in biomedicine Pub Date : 2024-09-29 DOI:10.1016/j.cmpb.2024.108445

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引用次数: 0

Abstract

Background and objective

This study aimed to investigate the impact of different stenotic degrees on platelet deposition in the left anterior descending branch of the coronary artery.

Methods

The idealized model of coronary artery stenosis of 30 %, 40 %, 50 %, 60 %, 70 % and four patient-specific models of 22.17 %, 34.88 %, 51.23 % and 62.96 % were established. A discrete phase model was used to calculate the deposition of platelet particles in blood.

Results

(1) As the stenotic degree increased from 30 % to 70 %, the maximum deposition rates were 4.23e^-² kg/(m² ·s), 3.47e^-² kg/(m² ·s), 0.14 kg/(m² ·s), 0.15 kg/(m² ·s), and 0.38 kg/(m² ·s), respectively. (2) The greater the stenotic degree, the more points of platelet deposition. (3) Platelets were mainly deposited at the proximal segment of mild stenosis. When the stenotic degree exceeded 50 %, the deposition position moved to the distal segment of the stenosis. (4) The results in the real coronary artery models were similar to those in the idealized model.

Conclusion

The study suggests that the location and number of platelet deposition are related to the degree of stenosis. Moderate to severe stenosis is more likely to spread downstream.

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不同狭窄程度对冠状动脉左前降支血小板沉积的影响。

背景和目的：本研究旨在探讨不同狭窄程度对冠状动脉左前降支血小板沉积的影响：建立了 30%、40%、50%、60%、70% 的理想化冠状动脉狭窄模型和 22.17%、34.88%、51.23%、62.96% 四种患者特异性模型。结果：（1）随着狭窄程度从 30% 增加到 70%，最大沉积率分别为 4.23e-2 kg/（m2 -s）、3.47e-2 kg/（m2 -s）、0.14 kg/（m2 -s）、0.15 kg/（m2 -s）和 0.38 kg/（m2 -s）。(2）狭窄程度越大，血小板沉积点越多。(3）血小板主要沉积在轻度狭窄的近端。当狭窄程度超过 50%时，血小板沉积位置转移到狭窄远端。(4）真实冠状动脉模型中的结果与理想化模型中的结果相似：研究表明，血小板沉积的位置和数量与狭窄程度有关。中度至重度狭窄更有可能向下游扩散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer methods and programs in biomedicine 工程技术-工程：生物医学

CiteScore

12.30

自引率

6.60%

发文量

601

审稿时长

135 days

期刊介绍： To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.