sB7-H4 is a diagnostic biomarker in epithelial ovarian cancer and correlates to platinum resistance.

IF 3.4 3区 医学 Q3 IMMUNOLOGY
Ying Zhou, Jingluan Tian, Yu Shen, Hansi Liang, Youguo Chen, Juan Wang, Yanzheng Gu
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Abstract

Ovarian cancer, with its high mortality rate among gynecological cancers, is often diagnosed late due to the lack of early diagnostic symptoms and biomarkers. The tumor immune microenvironment has become a focal point in cancer diagnostic and therapeutic research. Among these, B7-H4, a checkpoint protein, plays a crucial role in immune regulation and tumor suppression, contributing to immune evasion within the tumor microenvironment. This study aims to identify the concentration of soluble B7-H4(sB7-H4) in the plasma of patients with ovarian cancer and to evaluate its clinical significance. Through a comprehensive analysis involving enzyme-linked immunosorbent assay, immunohistochemistry, and multicolor immunofluorescence, we quantified sB7-H4 levels in patient plasma and ascites, correlating these findings with tissue expression and clinical outcomes. Results indicated a strong association between high sB7-H4 levels and advanced disease, surgical outcomes, lymphatic metastasis, and platinum resistance. When compared with traditional biomarkers CA125 and HE4, sB7-H4, especially in conjunction with these markers, enhances the diagnostic accuracy for epithelial ovarian cancer, offering insights into disease progression and therapeutic efficacy. This comprehensive analysis suggests that sB7-H4 is a promising biomarker for EOC, providing valuable insights into diagnosis, stage differentiation, treatment effectiveness, and prognosis.

sB7-H4 是上皮性卵巢癌的诊断生物标志物,与铂类抗药性相关。
在妇科癌症中,卵巢癌的死亡率很高,但由于缺乏早期诊断症状和生物标志物,卵巢癌往往诊断较晚。肿瘤免疫微环境已成为癌症诊断和治疗研究的焦点。其中,B7-H4作为一种检查点蛋白,在免疫调节和肿瘤抑制中起着至关重要的作用,有助于肿瘤微环境中的免疫逃避。本研究旨在确定卵巢癌患者血浆中可溶性B7-H4(sB7-H4)的浓度,并评估其临床意义。通过酶联免疫吸附试验、免疫组织化学和多色免疫荧光等综合分析,我们对患者血浆和腹水中的 sB7-H4 水平进行了量化,并将这些结果与组织表达和临床结果进行了关联分析。结果表明,高水平的sB7-H4与晚期疾病、手术结果、淋巴转移和铂类耐药之间存在密切联系。与传统的生物标记物 CA125 和 HE4 相比,sB7-H4(尤其是与这些标记物结合使用时)提高了上皮性卵巢癌诊断的准确性,并提供了对疾病进展和治疗效果的洞察力。这项综合分析表明,sB7-H4 是一种很有前景的 EOC 生物标记物,能为诊断、分期、治疗效果和预后提供有价值的信息。
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来源期刊
CiteScore
8.40
自引率
2.20%
发文量
101
审稿时长
3-8 weeks
期刊介绍: Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our understanding of the immunopathology of human disease and/or change clinical practice. The journal is focused on translational and clinical immunology and is among the foremost journals in this field, attracting high-quality papers from across the world. Translation is viewed as a process of applying ideas, insights and discoveries generated through scientific studies to the treatment, prevention or diagnosis of human disease. Clinical immunology has evolved as a field to encompass the application of state-of-the-art technologies such as next-generation sequencing, metagenomics and high-dimensional phenotyping to understand mechanisms that govern the outcomes of clinical trials.
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