A microglial compliment: controlling neuronal function from within

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2024-10-07 DOI:10.1038/s41392-024-01989-9

Dilara Hasavci, Thomas Blank

引用次数: 0

Abstract

A recent study published in Cell revealed that in the aging brain, the microglia-derived complement component C1q is internalized into neurons through endocytosis, integrates into ribonucleoprotein (RNP) complexes where it inhibits neuronal protein synthesis and alters the protein content. These findings demonstrate an unexpected intracellular function of C1q in neurons with significant implications for understanding age-related changes in brain function and potentially neurodegenerative diseases.¹

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小胶质细胞的赞美：从内部控制神经元功能

最近发表在《细胞》（Cell）杂志上的一项研究发现，在衰老的大脑中，小胶质细胞衍生的补体成分 C1q 通过内吞作用内化到神经元中，整合到核糖核蛋白（RNP）复合物中，抑制神经元蛋白质合成并改变蛋白质含量。这些发现证明了 C1q 在神经元中意想不到的细胞内功能，对理解与年龄相关的大脑功能变化以及潜在的神经退行性疾病具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.