Obese have comparable ankle brachial pressure index but higher β-cell function and insulin resistance as compared to normal-weight type 2 diabetes mellitus patients.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2024-10-05 DOI:10.1007/s00592-024-02379-x

Umashree Yadav, Nilesh Kumar, Kumar Sarvottam

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Abstract

Objectives: To compare ankle brachial pressure index (ABPI) in normal weight and obese/overweight type 2 diabetes mellitus patients (T2DM) to see the impact of obesity on the occurrence of peripheral artery disease (PAD) in T2DM patients. Secondly to investigate the relationship between ABPI, insulin resistance, and beta cell function and between adipocytokines and obesity parameters.

Methods: A total of 120 BMI-categorized Normal weight (NW) T2DM (n = 53) patients and obese/overweight T2DM (n = 67) patients were recruited in this study. ABPI measurements were performed for the assessment of PAD. The anthropometry and body composition of the patients were measured. Plasma fasting insulin, adiponectin, and IL-6 levels were measured by ELISA kits.

Results: ABPI scores were found to be comparable between both groups of patients (p = 0.787). A significant positive correlation was observed between ABPI and beta cell function. Insulin resistance was found to correlate positively while adiponectin negatively with obesity parameters.

Conclusion: The ABPI score was comparable between both groups of patients, suggesting that vascular complications may occur at the same rate in NW as well as in obese/overweight diabetic patients. The positive association of insulin resistance as well as the negative association of adiponectin with obesity parameters, are suggestive of the importance of body fat distribution in predicting insulin resistance and the inflammatory status of the cells.

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与正常体重的 2 型糖尿病患者相比，肥胖者的踝肱压指数相当，但其 β 细胞功能和胰岛素抵抗较高。

目的比较正常体重和肥胖/超重 2 型糖尿病患者（T2DM）的踝肱压指数（ABPI），以了解肥胖对 T2DM 患者外周动脉疾病（PAD）发生的影响。其次，研究 ABPI、胰岛素抵抗和β细胞功能之间的关系，以及脂肪细胞因子与肥胖参数之间的关系：本研究共招募了 120 名体重指数分类为正常体重（NW）的 T2DM 患者（53 人）和肥胖/超重 T2DM 患者（67 人）。进行 ABPI 测量以评估 PAD。对患者的人体测量和身体成分进行了测量。通过 ELISA 试剂盒测量血浆空腹胰岛素、脂肪连素和 IL-6 水平：两组患者的 ABPI 评分相当（p = 0.787）。在 ABPI 和 beta 细胞功能之间观察到明显的正相关。胰岛素抵抗与肥胖参数呈正相关，而脂肪连蛋白与肥胖参数呈负相关：结论：两组患者的 ABPI 评分相当，表明肥胖/超重糖尿病患者的血管并发症发生率可能相同。胰岛素抵抗与肥胖参数呈正相关，而脂肪连蛋白与肥胖参数呈负相关，这表明体脂分布在预测胰岛素抵抗和细胞炎症状态方面的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.