Neuro-inflammatory pathways in COVID-19-induced central nervous system injury: Implications for prevention and treatment strategies

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2024-10-03 DOI:10.1016/j.expneurol.2024.114984

Muhammad Liaquat Raza , Mustafa Hussain Imam , Warisha Zehra , Subia Jamil

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Abstract

This review explores the neuroinflammatory pathways underlying COVID-19-induced central nervous system (CNS) injury, with a focus on mechanisms of brain damage and strategies for prevention. A comprehensive literature review was conducted to summarize current knowledge on the pathways by which SARS-CoV-2 reaches the brain, the neuroinflammatory responses triggered by viral infection, neurological symptoms and long COVID. Results: We discuss the mechanisms of neuroinflammation in COVID-19, including blood-brain barrier disruption, cytokine storm, microglial activation, and peripheral immune cell infiltration. Additionally, we highlight potential strategies for preventing CNS injury, including pharmacological interventions, immunomodulatory therapies, and lifestyle modifications. Conclusively, Understanding the neuroinflammatory pathways in COVID-19-induced CNS injury is crucial for developing effective prevention and treatment strategies to protect brain health during and after viral infection.

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COVID-19 诱导的中枢神经系统损伤中的神经炎症途径：对预防和治疗策略的影响

这篇综述探讨了 COVID-19 引发中枢神经系统（CNS）损伤的神经炎症途径，重点是脑损伤的机制和预防策略。我们进行了全面的文献综述，总结了目前关于 SARS-CoV-2 到达大脑的途径、病毒感染引发的神经炎症反应、神经系统症状和长期 COVID 的知识。结果：我们讨论了 COVID-19 的神经炎症机制，包括血脑屏障破坏、细胞因子风暴、小胶质细胞活化和外周免疫细胞浸润。此外，我们还强调了预防中枢神经系统损伤的潜在策略，包括药物干预、免疫调节疗法和生活方式调整。总之，了解 COVID-19 诱导的中枢神经系统损伤的神经炎症途径对于制定有效的预防和治疗策略以保护病毒感染期间和之后的大脑健康至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.