Peroxisomal homeostasis in metabolic diseases and its implication in ferroptosis.

IF 8.2 2区 生物学 Q1 CELL BIOLOGY
Jiwei Han, Daheng Zheng, Pu-Ste Liu, Shanshan Wang, Xin Xie
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引用次数: 0

Abstract

Peroxisomes are dynamic organelles involved in various cellular processes, including lipid metabolism, redox homeostasis, and intracellular metabolite transfer. Accumulating evidence suggests that peroxisomal homeostasis plays a crucial role in human health and disease, particularly in metabolic disorders and ferroptosis. The abundance and function of peroxisomes are regulated by a complex interplay between biogenesis and degradation pathways, involving peroxins, membrane proteins, and pexophagy. Peroxisome-dependent lipid metabolism, especially the synthesis of ether-linked phospholipids, has been implicated in modulating cellular susceptibility to ferroptosis, a newly discovered form of iron-dependent cell death. This review discusses the current understanding of peroxisome homeostasis, its roles in redox regulation and lipid metabolism, and its implications in human diseases. We also summarize the main mechanisms of ferroptosis and highlight recent discoveries on how peroxisome-dependent metabolism and signaling influence ferroptosis sensitivity. A better understanding of the interplay between peroxisomal homeostasis and ferroptosis may provide new insights into disease pathogenesis and reveal novel therapeutic strategies for peroxisome-related metabolic disorders and ferroptosis-associated diseases.

代谢性疾病中的过氧化物酶体平衡及其在铁变态反应中的作用。
过氧物酶体是一种动态细胞器,参与各种细胞过程,包括脂质代谢、氧化还原平衡和细胞内代谢物转移。越来越多的证据表明,过氧化物酶体的平衡在人类健康和疾病中起着至关重要的作用,尤其是在代谢紊乱和铁中毒中。过氧化物酶体的丰度和功能受生物生成和降解途径之间复杂的相互作用调节,其中涉及过氧化物酶、膜蛋白和食酶体。过氧化物酶体依赖的脂质代谢,尤其是醚键磷脂的合成,与调节细胞对铁凋亡的易感性有关,铁凋亡是一种新发现的铁依赖性细胞死亡形式。这篇综述讨论了目前对过氧化物酶体稳态的认识、其在氧化还原调节和脂质代谢中的作用及其对人类疾病的影响。我们还总结了铁中毒的主要机制,并重点介绍了有关过氧化物酶体依赖性代谢和信号转导如何影响铁中毒敏感性的最新发现。更好地理解过氧化物酶体平衡和铁变态反应之间的相互作用可能会为疾病的发病机制提供新的见解,并为过氧化物酶体相关代谢紊乱和铁变态反应相关疾病揭示新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
0.00%
发文量
180
期刊介绍: Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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