Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications.

IF 2.5 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Lucas Henrique Junges, Marcelo Müller-Santos
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引用次数: 0

Abstract

Tryptamines play diverse roles as neurotransmitters and psychoactive compounds found in various organisms. Psilocybin, a notable tryptamine, has garnered attention for its therapeutic potential in treating mental health disorders like depression and anxiety. Despite its promising applications, current extraction methods for psilocybin are labor-intensive and economically limiting. We suggest biocatalysis as a sustainable alternative, leveraging enzymes to synthesize psilocybin and other tryptamines efficiently. By elucidating psilocybin biosynthesis pathways, researchers aim to advance synthetic methodologies and industrial applications. This review underscores the transformative potential of biocatalysis in enhancing our understanding of tryptamine biosynthesis and facilitating the production of high-purity psilocybin and other tryptamines for therapeutic and research use.

探索迷幻药和其他色胺的生物催化:酶途径、合成策略和工业影响。
色胺作为神经递质和精神活性化合物在各种生物体内发挥着不同的作用。迷幻药是一种著名的色胺,因其在治疗抑郁症和焦虑症等精神疾病方面的治疗潜力而备受关注。尽管其应用前景广阔,但目前提取迷幻药的方法需要耗费大量人力,且经济效益有限。我们建议将生物催化作为一种可持续的替代方法,利用酶来高效合成迷幻药和其他色胺。通过阐明迷幻药的生物合成途径,研究人员旨在推进合成方法和工业应用。这篇综述强调了生物催化的变革潜力,有助于加深我们对色胺生物合成的了解,促进高纯度迷幻药和其他色胺的生产,用于治疗和研究。
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来源期刊
Biotechnology Progress
Biotechnology Progress 工程技术-生物工程与应用微生物
CiteScore
6.50
自引率
3.40%
发文量
83
审稿时长
4 months
期刊介绍: Biotechnology Progress , an official, bimonthly publication of the American Institute of Chemical Engineers and its technological community, the Society for Biological Engineering, features peer-reviewed research articles, reviews, and descriptions of emerging techniques for the development and design of new processes, products, and devices for the biotechnology, biopharmaceutical and bioprocess industries. Widespread interest includes application of biological and engineering principles in fields such as applied cellular physiology and metabolic engineering, biocatalysis and bioreactor design, bioseparations and downstream processing, cell culture and tissue engineering, biosensors and process control, bioinformatics and systems biology, biomaterials and artificial organs, stem cell biology and genetics, and plant biology and food science. Manuscripts concerning the design of related processes, products, or devices are also encouraged. Four types of manuscripts are printed in the Journal: Research Papers, Topical or Review Papers, Letters to the Editor, and R & D Notes.
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