Differences in survival of patients with multiple myeloma in rural versus metropolitan regions: Analysis of population data of an Australian local health district.

IF 1.9 4区医学 Q2 NURSING

Australian Journal of Rural Health Pub Date : 2024-10-03 DOI:10.1111/ajr.13189

Sylvia Ai, Amarinder Thind, Gurdeep Parmar

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引用次数: 0

Abstract

Objective: The objective of this study is to determine if there are differences in outcome for patients diagnosed with multiple myeloma in a rural setting compared to a metropolitan setting and which factors influence these outcomes.

Design: Retrospective cohort study.

Setting: Illawarra Shoalhaven Local Health District.

Participants: A total of 391 patients diagnosed with multiple myeloma between 2000 and 2022.

Main outcome measures: Treatment and survival outcomes of these patients.

Results: Patients being treated in a rural cancer care centre had lower overall survival compared to those treated at a metropolitan cancer care centre (median OS = 44.4 months vs. 80.2 months, p = 0.002), despite access to similar treatments by the same group of haematologists. There was a significantly higher rate of upfront autologous transplantation (38% vs. 20%, p = 0.001) and higher rate of inclusion in clinical trials (16% vs. 7%, p = 0.021) in patients treated at a metropolitan cancer care centre compared to the rural cancer care centre.

Conclusions: Multiple myeloma patients treated at a rural centre had shorter survival compared to patients treated at a metropolitan centre, and this may be related to lower rates of autologous transplantation and inclusion in clinical trials.

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农村地区与大都市地区多发性骨髓瘤患者存活率的差异：澳大利亚一个地方卫生区的人口数据分析。

研究目的本研究的目的是确定在农村地区确诊的多发性骨髓瘤患者的预后与大都市相比是否存在差异，以及哪些因素会影响这些预后：设计：回顾性队列研究：伊拉瓦拉肖尔黑文地方卫生区：2000年至2022年期间被诊断为多发性骨髓瘤的391名患者：这些患者的治疗和生存结果：结果：与在大都市癌症治疗中心接受治疗的患者相比，在农村癌症治疗中心接受治疗的患者总生存期较低（中位OS = 44.4个月 vs. 80.2个月，p = 0.002），尽管同一组血液学专家提供了类似的治疗。与农村癌症治疗中心相比，在大都市癌症治疗中心接受治疗的患者接受前期自体移植的比例明显更高（38%对20%，p=0.001），纳入临床试验的比例也更高（16%对7%，p=0.021）：结论：在农村中心接受治疗的多发性骨髓瘤患者的生存期比在大都市中心接受治疗的患者短，这可能与自体移植率和临床试验纳入率较低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Journal of Rural Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.30

自引率

16.70%

发文量

122

审稿时长

12 months

期刊介绍： The Australian Journal of Rural Health publishes articles in the field of rural health. It facilitates the formation of interdisciplinary networks, so that rural health professionals can form a cohesive group and work together for the advancement of rural practice, in all health disciplines. The Journal aims to establish a national and international reputation for the quality of its scholarly discourse and its value to rural health professionals. All articles, unless otherwise identified, are peer reviewed by at least two researchers expert in the field of the submitted paper.