Perioperative intravenous lignocaine for pediatric postoperative pain-A systematic review and meta-analysis.

IF 1.7 4区医学 Q2 ANESTHESIOLOGY

Pediatric Anesthesia Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI:10.1111/pan.15015

Aakriti Gupta, Vighnesh Ashok

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引用次数: 0

Abstract

Background: Intravenous lignocaine has been used as an analgesic adjunct in pediatric surgical patients, although its efficacy is still unclear.

Objective: We aimed to clarify the efficacy of perioperative intravenous lignocaine (bolus followed by an infusion) on pediatric postoperative pain outcomes.

Design: A systematic review and meta-analysis.

Data sources: PubMed, EMBASE, Web of Science, Google Scholar (inception to June 2024).

Eligibility criteria: Studies involving pediatric patients (≤18 years) undergoing surgery under general anesthesia with one group receiving perioperative intravenous lignocaine (bolus followed by infusion) and the other group receiving placebo. The primary outcome was 24-h postoperative opioid consumption. Postoperative pain scores and the need for rescue analgesia were the secondary outcomes.

Results: Seven studies (n = 415) were included in the final meta-analysis. The use of intravenous lignocaine significantly reduced the morphine consumption in the first 24 h after surgery, compared to placebo (SMD -1.31, 95% CI -2.18 to -0.43, p = 0.003). A meta-analysis could not be performed for the secondary outcomes.

Conclusion: There is low quality evidence to suggest that perioperative intravenous lignocaine bolus followed by an infusion significantly reduced the opioid consumption on the first postoperative day in pediatric surgical patients. The effects of perioperative lignocaine on postoperative pain scores and the need for rescue analgesia are uncertain.

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围手术期静脉注射木质素卡因治疗小儿术后疼痛--系统综述和荟萃分析。

背景：静脉注射木质素卡因已被用作儿科手术患者的镇痛辅助药物，但其疗效仍不明确：我们旨在明确围手术期静脉注射木质素（栓剂后输注）对小儿术后疼痛结果的疗效：设计：系统回顾和荟萃分析：数据来源：PubMed、EMBASE、Web of Science、Google Scholar（开始至 2024 年 6 月）：涉及在全身麻醉下接受手术的儿科患者（≤18 岁）的研究，其中一组患者在围手术期静脉注射利格诺卡因（栓剂后输注），另一组患者服用安慰剂。主要结果是术后24小时的阿片类药物消耗量。术后疼痛评分和抢救性镇痛需求是次要结果：最终荟萃分析纳入了七项研究（n = 415）。与安慰剂相比，静脉注射木质素可显著减少术后头24小时的吗啡用量（SMD -1.31，95% CI -2.18 to -0.43，p = 0.003）。无法对次要结果进行荟萃分析：有低质量证据表明，围手术期静脉注射木质素后再输液可显著减少小儿外科手术患者术后第一天的阿片类药物用量。围手术期使用木质素卡因对术后疼痛评分和抢救性镇痛需求的影响尚不确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Anesthesia 医学-麻醉学

CiteScore

3.20

自引率

11.80%

发文量

222

审稿时长

3-8 weeks

期刊介绍： Devoted to the dissemination of research of interest and importance to practising anesthetists everywhere, the scientific and clinical content of Pediatric Anesthesia covers a wide selection of medical disciplines in all areas relevant to paediatric anaesthesia, pain management and peri-operative medicine. The International Editorial Board is supported by the Editorial Advisory Board and a team of Senior Advisors, to ensure that the journal is publishing the best work from the front line of research in the field. The journal publishes high-quality, relevant scientific and clinical research papers, reviews, commentaries, pro-con debates, historical vignettes, correspondence, case presentations and book reviews.