Short communications: Endothelin-1 in cardiac allograft vasculopathy

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2024-10-01 DOI:10.1016/j.mvr.2024.104751

George R. Abraham , Anthony P. Davenport , Stephen P. Hoole

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引用次数: 0

Abstract

Introduction

Cardiac allograft vasculopathy (CAV) is a leading cause of death following heart transplant. Endothelin-1 (ET-1) is a highly potent vasoconstrictor peptide derived from the vascular endothelium with multiple biological actions known to be relevant for CAV. We assessed the trans-myocardial gradient (TMG: coronary sinus minus coronary artery concentration: negative = extraction, positive = secretion) of ET-1 in heart transplant patients to determine correlations with angiographic, Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT) features of CAV.

Results

Vessels with more severe CAV demonstrated significantly higher (more positive) ET-1 TMG (IVUS Stanford Grade IV: −0.05 [−0.21, 0.13] pg/ml versus Stanford Grade I-III: −0.31 [−0.64, −0.11] pg/ml, p = 0.01). ET-1 TMG was positively correlated with mean intimal thickness on both IVUS and OCT (IVUS: Kendall's tau-b = 0.254, p = 0.02 and OCT: Kendall's tau-b = 0.344, p < 0.0001). Patients who died had net ET-1 release compared with surviving patients (died: 0.21 [0.19–0.24] versus surviving: −0.28 [−0.52, −0.17], p = 0.01).

Conclusion

In heart transplant patients, coronary arteries with more intimal thickening are associated with a higher (more positive) trans-myocardial gradient of ET-1, suggesting that up-regulated ET-1 release in the coronary circulation may be permissive for the development of CAV.

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短讯：心脏移植血管病变中的内皮素-1。

导言：心脏移植物血管病变（CAV）是心脏移植后死亡的主要原因。内皮素-1（ET-1）是一种来自血管内皮的强效血管收缩肽，具有多种已知与 CAV 相关的生物作用。我们评估了心脏移植患者体内 ET-1 的跨心肌梯度（TMG：冠状动脉窦减去冠状动脉的浓度：负=提取，正=分泌），以确定其与 CAV 的血管造影、血管内超声（IVUS）和光学相干断层扫描（OCT）特征的相关性：结果：CAV 更严重的血管显示出更高的（更阳性的）ET-1 TMG（IVUS Stanford IV 级：-0.05 [-0.21, 0.13] pg/ml 与 Stanford I-III 级：-0.31 [-0.64, -0.11] pg/ml，p = 0.01）。ET-1 TMG 与 IVUS 和 OCT 的平均内膜厚度呈正相关（IVUS：ET-1TMG与IVUS和OCT的平均内膜厚度呈正相关（IVUS：Kendall's tau-b = 0.254，p = 0.02；OCT：Kendall's tau-b = 0.344，p 结论：ET-1TMG与内膜厚度呈正相关：在心脏移植患者中，内膜增厚的冠状动脉与更高的（更正向的）ET-1跨心肌梯度相关，这表明冠状动脉循环中上调的ET-1释放可能会导致CAV的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.