INDIVIDUAL ARTCLE: Pathophysiologic Targets of Acne Treatment.

IF 1.5 4区 医学 Q3 DERMATOLOGY
Journal of Drugs in Dermatology Pub Date : 2024-10-01
Emmy M Graber, Natalie Vincent
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引用次数: 0

Abstract

Acne vulgaris is an extremely common dermatologic condition. Individuals with acne present not only to dermatologists, but also to internists, family medicine physicians, pediatricians, estheticians, and beauty counters alike in search of a treatment. The diagnosis of acne is relatively straightforward, leading many to believe that acne is a simple condition. However, the pathophysiology of acne is anything but simple. Decades of research has ultimately revealed a complex interaction of pathogenic factors that lead to acne. This includes sebum production, C. acnes colonization, inflammation, and follicular hyperkeratinization. Understanding each of these features has been fundamental to the development of anti-acne medications. Topical agents are often used as an initial therapy given their safety and efficacy. While some topical therapies have been used for decades, new creams, gels, and lotions continue to be added to the list of approved acne treatments. Given the number of topical acne products on the market, we present an updated review of the current landscape of topical acne treatments and how each choice functions mechanistically to fight against acne. J Drugs Dermatol. 2024;23:10(Suppl 1):s4-11.

个人文章:痤疮治疗的病理生理学目标。
寻常痤疮是一种极为常见的皮肤病。痤疮患者不仅向皮肤科医生求诊,还向内科医生、家庭医生、儿科医生、美容师和美容专柜寻求治疗。痤疮的诊断相对简单,因此很多人认为痤疮是一种简单的疾病。然而,痤疮的病理生理学却并不简单。数十年的研究最终揭示了导致痤疮的各种致病因素之间复杂的相互作用。这包括皮脂分泌、痤疮丙酸杆菌定植、炎症和毛囊角化过度。对这些特征的了解是开发抗痤疮药物的基础。鉴于其安全性和有效性,外用药物通常被用作初始疗法。虽然有些外用疗法已经使用了几十年,但不断有新的药膏、凝胶和乳液加入到批准的痤疮治疗清单中。鉴于市场上的痤疮外用产品数量众多,我们将对目前的痤疮外用治疗方法以及每种选择如何从机理上对抗痤疮进行最新评述。J Drugs Dermatol.2024;23:10(Suppl 1):s4-11.
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来源期刊
CiteScore
2.20
自引率
13.30%
发文量
289
审稿时长
3-6 weeks
期刊介绍: The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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