Immunotherapy and new treatments.

IF 3 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI:10.1097/ACI.0000000000001031

Yaroslav Andrew Jakymec, Justin Greiwe, Jonathan A Bernstein

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引用次数: 0

Abstract

Purpose of review: This review comes at a time where new techniques in immunotherapy administration are being developed, new innovations are being incorporated to standard techniques, and new regulations are being adopted regarding the creation and storage of allergen extracts. Prior to the release of updated practice parameters regarding allergic rhinitis and immunotherapies, this review article provides a synopsis of current recommendations, a comparison of the practices in the United States and those of Europe, and an examination of experimental methods that are being studied.

Recent findings: This article seeks to review and discuss the various methods of administration, build up schedules, efficacy, effect on other atopic symptoms, and safety associated with allergen immunotherapy.

Summary: Innovations in standard techniques, such as new allergoids for SCIT, appear to be effective in improving symptoms and increasing IgG levels for grass allergens. Data for newer techniques is less clear. There appears to be increased treatment-related adverse events for ILIT, worse symptom scores compared with placebo for IDIT, and insufficient studies regarding the effectiveness of EPIT for aeroallergens. New regulations seek to standardize the documentation, storage, and creation of allergen extracts.

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免疫疗法和新疗法

审查目的：本综述是在免疫疗法管理新技术不断发展、标准技术不断创新、过敏原提取物的制作和储存新规定不断出台的背景下撰写的。在有关过敏性鼻炎和免疫疗法的最新实践参数发布之前，这篇综述文章概述了当前的建议，对美国和欧洲的实践进行了比较，并探讨了正在研究的实验方法：摘要：标准技术的创新，如用于 SCIT 的新型过敏原，在改善症状和提高草过敏原 IgG 水平方面似乎很有效。新技术的数据则不太明确。ILIT 的治疗相关不良事件似乎有所增加，IDIT 的症状评分比安慰剂差，EPIT 对航空过敏原的有效性研究不足。新法规旨在规范过敏原提取物的记录、储存和制作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.