Cancer Genomes Sometimes Take the Longest Evolutionary Road.

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-10-04 DOI:10.1158/2159-8290.CD-24-1017

Alison M Taylor

引用次数: 0

Abstract

Baker and colleagues developed a new algorithm called "Gain Route Identification and Timing In Cancer" (GRITIC) to uncover the path of chromosomal evolution in a tumor, particularly in the context of whole-genome duplication. Their approach found that tumors with genome doubling frequently take an indirect path from one copy number state to another. In addition, the timing of genome doubling within a tumor's evolution impacts its consequences on downstream chromosomal instability. See related article by Baker et al., p. 1810.

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癌症基因组有时走最长的进化之路

贝克及其同事开发了一种名为 "癌症增益路径识别与时间"（GRITIC）的新算法，用于揭示肿瘤中染色体的进化路径，尤其是在全基因组复制的情况下。他们的方法发现，出现基因组倍增的肿瘤经常从一种拷贝数状态间接进入另一种拷贝数状态。此外，肿瘤进化过程中基因组加倍的时间也会影响其对下游染色体不稳定性的影响。参见 Baker 等人的相关文章，第 1810 页。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.