Diagnostic Decision Point for IgE-Mediated Wheat Allergy in Children.

IF 4.1 2区医学 Q2 ALLERGY

Allergy, Asthma & Immunology Research Pub Date : 2024-09-01 DOI:10.4168/aair.2024.16.5.555

Yoonha Hwang, Jihyun Kim, Kangmo Ahn, Kyunguk Jeong, Sooyoung Lee, Soo-Jong Hong, You Hoon Jeon, Yoon Hee Kim, Meeyong Shin, Tae Won Song, Minyoung Jung, Minji Kim, Taek Ki Min, Ji Young Lee, Min Jung Kim, Yong Ju Lee, Jeongmin Lee, Young A Park, Gwang Cheon Jang, Young Min Ahn, So-Yeon Lee, Jeong Hee Kim

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Abstract

The diagnostic decision point can help diagnose food allergies while reducing the need for oral food challenge (OFC) tests. We performed a multicenter survey of children aged 0-7 years from January 1, 2018 to March 31, 2022. A total of 231 children were recruited from 18 institutions. Wheat allergy (WA) or non-wheat allergy (NWA) was determined on the basis of OFC results and symptoms. There were no differences in age, sex, family history of allergy or allergic comorbidities between the WA and NWA groups. According to receiver operating characteristic analysis for wheat-specific immunoglobulin E (IgE), the optimal cutoff value, positive decision point, and negative decision point were 10.2, 33.5, and 0.41 kU/L, respectively. For the ω-5 gliadin-specific IgE, their values were 0.69, 3.88, and 0.01 kU/L, respectively. This new diagnostic decision point may be used to diagnose WA in Korean children.

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儿童 IgE 型小麦过敏的诊断决定点。

诊断决策点有助于诊断食物过敏，同时减少对口服食物挑战（OFC）试验的需求。我们在 2018 年 1 月 1 日至 2022 年 3 月 31 日期间对 0-7 岁儿童进行了一次多中心调查。共从 18 家机构招募了 231 名儿童。小麦过敏（WA）或非小麦过敏（NWA）是根据 OFC 结果和症状确定的。小麦过敏组和非小麦过敏组在年龄、性别、过敏家族史或过敏并发症方面没有差异。根据小麦特异性免疫球蛋白 E (IgE) 的接收器操作特征分析，最佳临界值、阳性判定点和阴性判定点分别为 10.2、33.5 和 0.41 kU/L。而ω-5麦胶蛋白特异性 IgE 的最佳临界值分别为 0.69、3.88 和 0.01 kU/L。这一新的诊断决定点可用于诊断韩国儿童的 WA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergy, Asthma & Immunology Research ALLERGY-IMMUNOLOGY

CiteScore

6.10

自引率

6.80%

发文量

审稿时长

>12 weeks

期刊介绍： The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.