Individual and combined effects of muscle strength and visceral adiposity on incident prediabetes and type 2 diabetes in a longitudinal cohort of midlife Asian women

IF 5.7 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2024-10-04 DOI:10.1111/dom.15995

Beverly W. X. Wong MPH, Darren Y. Z. Tan BSc (Hons), Ling-Jun Li PhD, Eu-Leong Yong FRCOG

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Abstract

Aim

To investigate the independent and combined effects of muscle strength and visceral adiposity on prediabetes and type 2 diabetes incidence among midlife women.

Materials and Methods

In this prospective study of midlife women (mean age 56.4 years), visceral adiposity, defined as visceral adipose tissue (VAT) >131 cm² measured by dual energy X-ray absorptiometry, and poor combined muscle strength, defined as handgrip strength <18 kg and/or five-time repeated chair stand test performance ≥12 s, were determined at baseline between 2014 and 2016. After 6.6 years, the effects of VAT and muscle strength on risk of incident prediabetes (fasting blood glucose 5.6–6.9 mmol/L) and type 2 diabetes (fasting blood glucose levels ≥7 mmol/L, medication use, or physician diagnosis) were examined using modified Poisson regression analysis.

Results

Among the 733 initially normoglycaemic participants, 150 (20.5%) developed prediabetes or type 2 diabetes. Women with both poor combined muscle strength and high VAT had the highest risk for both prediabetes and type 2 diabetes (adjusted relative risk [aRR] 2.63, 95% confidence interval [CI] 1.81–3.82). In comparison, high VAT alone increased risk by 1.78-fold (95% CI 1.12–2.84). Stratification analyses showed that among women with low muscle strength, high VAT demonstrated increased risks of prediabetes and type 2 diabetes (aRR 2.84, 95% CI 1.95–4.14) compared to those with normal strength (aRR 1.66, 95% CI 1.04–2.65).

Conclusions

Low combined muscle strength with high VAT poses a greater risk for the development of prediabetes and type 2 diabetes than high VAT alone. Muscle strengthening should be promoted alongside weight loss in diabetes prevention.

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中年亚洲女性纵向队列中肌肉力量和内脏脂肪对糖尿病前期和 2 型糖尿病发病率的单独和综合影响。

目的：研究肌肉力量和内脏脂肪对中年女性糖尿病前期和 2 型糖尿病发病率的独立和综合影响：在这项针对中年女性（平均年龄 56.4 岁）的前瞻性研究中，通过双能 X 射线吸收测量法测量的内脏脂肪组织（VAT）>131 平方厘米和以手握力定义的肌肉力量低下的综合影响结果：在 733 名最初血糖正常的参与者中，有 150 人（20.5%）发展为糖尿病前期或 2 型糖尿病。同时具有综合肌力差和高 VAT 的女性罹患糖尿病前期和 2 型糖尿病的风险最高（调整后相对风险 [aRR] 2.63，95% 置信区间 [CI] 1.81-3.82）。相比之下，单纯的高 VAT 会使风险增加 1.78 倍（95% 置信区间为 1.12-2.84）。分层分析显示，在低肌力女性中，与正常肌力女性（aRR 1.66，95% CI 1.04-2.65）相比，高VAT增加了糖尿病前期和2型糖尿病的风险（aRR 2.84，95% CI 1.95-4.14）：结论：与单纯的高 VAT 相比，低综合肌力和高 VAT 更容易导致糖尿病前期和 2 型糖尿病。在预防糖尿病的过程中，应在减轻体重的同时加强肌肉力量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.