PKM2-G-quadruplex interactions conspire to regulate the cancer transcriptome

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.09.013

Prakash Kharel, Pavel Ivanov

引用次数: 0

Abstract

In this issue of Molecular Cell, Anastasakis et al. describe a novel function of the metabolic enzyme PKM2 as an RNA G-quadruplex binding protein, which could contribute to cancer biology.

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PKM2-G-四叠体相互作用共同调控癌症转录组

在本期《分子细胞》（Molecular Cell）杂志上，Anastasakis 等人描述了代谢酶 PKM2 作为 RNA G-quadruplex 结合蛋白的一种新功能，它可能有助于癌症生物学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.