Hepatocellular Carcinoma among Patients with Chronic Liver Disease in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

IF 0.5 4区医学 Q3 Medicine

Journal of Nepal Medical Association Pub Date : 2024-02-29 DOI:10.31729/jnma.8488

Arun Gnawali, Rahul Pathak, Dinesh Koirala, Rajesh Pandey, Rabin Hamal, Anurag Jha, Brindeswari Kafle Bhandari, Siddinath Gyawali

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引用次数: 0

Abstract

Introduction: Hepatocellular carcinoma is the most common primary liver cancer. Viral hepatitis, alcohol abuse, and autoimmune hepatitis are the common causes of hepatocellular carcinoma. Usually patients present at advanced stages where curative treatment is no longer possible. This study aimed to find the prevalence of hepatocellular carcinoma among patients with chronic liver disease in a tertiary care centre.

Methods: This is a descriptive cross-sectional study conducted in a single tertiary care centre from March 2020 to August 2022. The study was done among inpatients of the Department of Gastroenterology after ethical approval from the Institutional Review Committee. A total population sampling method was used and data were collected using predetermined proformas. Point estimate at 95% Confidence Interval was calculated.

Results: Among 1440 patients, hepatocellular carcinoma was seen in 54 (3.75%) (2.77-4.73, 95% Confidence Interval). At the time of diagnosis, 48 (88.89%) were symptomatic. The presenting symptoms were weight loss seen in 35 (64.81%) being the most common. Out of them, 37 (68.52%) consumed alcohol and 40 (74.07%) smoked cigarettes.

Conclusions: Hepatocellular carcinoma is a notable concern. Alcohol-related liver cirrhosis is the most frequent condition encountered in patients with hepatocellular carcinoma in our setting.

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一家三级医疗中心慢性肝病患者中的肝细胞癌：描述性横断面研究。

简介：肝细胞癌是最常见的原发性肝癌：肝细胞癌是最常见的原发性肝癌。病毒性肝炎、酗酒和自身免疫性肝炎是导致肝细胞癌的常见原因。患者通常处于晚期，已无法进行根治性治疗。本研究旨在了解一家三级医疗中心的慢性肝病患者中肝细胞癌的发病率：这是一项描述性横断面研究，于 2020 年 3 月至 2022 年 8 月在一家三级医疗中心进行。在获得机构审查委员会的伦理批准后，该研究在消化内科住院患者中进行。研究采用总人口抽样法，并使用预定表格收集数据。计算出 95% 置信区间的点估计值：在 1440 名患者中，54 人（3.75%）患有肝细胞癌（2.77-4.73，95% 置信区间）。确诊时，48 例（88.89%）有症状。35例（64.81%）最常见的症状是体重减轻。其中，37 人（68.52%）饮酒，40 人（74.07%）吸烟：结论：肝细胞癌是一个值得关注的问题。在我们的病例中，与酒精相关的肝硬化是肝细胞癌患者最常见的病症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nepal Medical Association PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-MEDICINE, GENERAL & INTERNAL

CiteScore

1.00

自引率

0.00%

发文量

233

审稿时长

>12 weeks

期刊介绍： Journal of Nepal Medical Association is an internationally peer-reviewed, MedLine/PubMed indexed, a monthly general medical journal published by Nepal Medical Association. JNMA is the first and oldest medical journal from Nepal since 1963 AD.