Use of multiparametric MRI to noninvasively assess iodinated contrast-induced acute kidney injury

IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yongfang Wang , Bin Wang , Jiangbo Qin , Haili Yan , Haoyuan Chen , Jinxia Guo , Pu-Yeh Wu , Xiaochun Wang
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Abstract

Purpose

To gauge the utility of multiparametric MRI in characterizing pathologic changes after iodinated contrast-induced acute kidney injury (CI-AKI) in rats.

Methods

We randomly grouped 24 rats injected with 8 g iodine/kg of body weight (n = 6 each) and 6 rats injected with saline as controls. All rats underwent T1, T2 mapping and diffusion kurtosis imaging (DKI) after contrast injection at 0 (control), 1, 3, 7, 13 days. T1, T2, and mean kurtosis (MK) values were performed in renal outer/inner stripes of outer medulla (OSOM and ISOM) and cortex (CO), and their diagnosis performance for CI-AKI also been evaluated. Serum creatinine (SCr), insulin-like growth factor-binding protein 7 (IGFBP7), tissue inhibitor metalloproteinase 2 (TIMP-2), aquaporin-1 (AQP1), α-smooth muscle actin (α-SMA), and histologic indices were examined.

Results

Compared with controls, urinary concentrations of both TIMP-2 and IGFBP7 were obviously elevated from Day 1 to Day 13 (all p < 0.05). T2 values were significantly higher than control group for Days 1 and 3, and T1 and MK increased were more remarkable at all time points (Days 1–13) in CI-AKI (all p < 0.05) than control group. Changes in T1 and MK strongly correlated with renal injury scores of all anatomical compartments and with expression levels of AQP1 and moderately correlated with α-SMA. Changes in T2 values correlating moderately with renal scores of CO, ISOM and OSOM and AQP1. The MK obtained the highest area under the receiver operating characteristic (ROC) curve of 0.846 with a sensitivity of 70.8 % and specificity of 88.9 %.

Conclusions

Combined use of multiparametric MRI could be a valid noninvasive method for comprehensive monitoring of CI-AKI. Among these parameters, MK may achieve the best diagnostic performance for CI-AKI.
使用多参数磁共振成像技术无创评估碘对比剂诱发的急性肾损伤。
目的:评估多参数磁共振成像在描述大鼠碘对比剂诱发急性肾损伤(CI-AKI)后病理变化方面的实用性:我们将 24 只注射了 8 克碘/千克体重的大鼠(每组 6 只)和 6 只注射了生理盐水的大鼠随机分组,作为对照组。所有大鼠在注射对比剂后的 0 天(对照组)、1 天、3 天、7 天和 13 天均接受了 T1、T2 图谱和扩散峰度成像(DKI)检查。在肾外侧髓质(OSOM 和 ISOM)和皮质(CO)的外侧/内侧条带进行了 T1、T2 和平均峰度(MK)值测定,并评估了它们对 CI-AKI 的诊断性能。研究人员还检测了血清肌酐(SCr)、胰岛素样生长因子结合蛋白7(IGFBP7)、组织抑制剂金属蛋白酶2(TIMP-2)、水光素-1(AQP1)、α-平滑肌肌动蛋白(α-SMA)以及组织学指标:与对照组相比,从第 1 天到第 13 天,尿液中 TIMP-2 和 IGFBP7 的浓度均明显升高(均为 p):联合使用多参数磁共振成像是全面监测 CI-AKI 的有效无创方法。在这些参数中,MK可能是诊断CI-AKI的最佳指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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