Therapeutic effect of exosomes derived from Schwann cells in the repair of peripheral nerve injury

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-09-30 DOI:10.1016/j.lfs.2024.123086

引用次数: 0

Abstract

Peripheral nerve injury (PNI) can cause nerve demyelination, neuronal apoptosis, axonal atrophy, inflammatory infiltration, glial scar formation, and other pathologies that can lead to sensory and motor dysfunction and seriously affect the psychosomatic health of patients. There is currently no effective treatment method, so exploring a promising treatment method is of great significance. Several studies have revealed the therapeutic roles of Schwann cells (SCs) and their exosomes in nerve injury repair. Exosomes are extracellular nanovesicles secreted by cells that act as key molecules in intercellular communication. Progress has been made in understanding the role of exosomes derived from SCs (SC-EXOs) in peripheral nerve regeneration, including the promotion of axonal regeneration and myelin formation, anti-inflammation, vascular regeneration, neuroprotection, and neuroregulation. Therefore, in this paper, we summarize the functional characteristics of SC-EXOs and discuss their potential therapeutic effects on PNI repair as well as some existing problems and future challenges.

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源自 SC 的外泌体在修复周围神经损伤中的治疗效果。

周围神经损伤（PNI）可引起神经脱髓鞘、神经元凋亡、轴突萎缩、炎症浸润、胶质瘢痕形成等病变，导致感觉和运动功能障碍，严重影响患者的心身健康。目前尚无有效的治疗方法，因此探索一种有前景的治疗方法意义重大。多项研究揭示了许旺细胞（SC）及其外泌体在神经损伤修复中的治疗作用。外泌体是细胞分泌的胞外纳米颗粒，是细胞间通信的关键分子。人们对源自 SCs 的外泌体（SC-EXOs）在周围神经再生中的作用的认识已取得进展，包括促进轴突再生和髓鞘形成、抗炎、血管再生、神经保护和神经调节。因此，我们在本文中总结了 SC-EXOs 的功能特点，并讨论了它们对 PNI 修复的潜在治疗效果以及一些现有问题和未来挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.