Virulence Potential of ESBL-Producing Escherichia coli Isolated during the Perinatal Period.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2024-10-22 DOI:10.1055/a-2427-9065

Hong Yin, Vilma Blomberg, Liwei Sun, ChunXia Yin, Susanne Sütterlin

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引用次数: 0

Abstract

Objective: The aim of the study was to investigate the virulence factors in Escherichia coli producing extended-spectrum β-lactamase (ESBL) derived from the perinatal fecal colonization flora of mothers and their newborns in a Chinese obstetric ward.

Study design: Rectal swabs were obtained from mothers prenatally and from their newborns postnatally, and analyzed for ESBL-producing Escherichia coli. The isolates were then whole-genome sequenced.

Results: Maternal and neonatal colonization by ESBL-producing E. coli in a Chinese obstetric ward was 18% (31/177) and 5% (9/170), respectively. Fecal ESBL-producing isolates exhibited a significantly lower frequency of virulence factors compared with invasive E. coli.

Conclusion: Providing balanced information on screening results is essential, along with conducting a risk assessment for antibiotic treatment strategies.

Key points: · High ESBL E. coli colonization rates in mothers and neonates perinatally. · Fecal ESBL-producing E. coli showed fewer virulence traits.. · ESBL-producing E. coli knowledge may prompt antibiotic overuse..

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围产期分离的产ESBL大肠埃希菌的毒性潜力。

研究目的本研究旨在调查中国产科病房产妇及其新生儿围产期粪便定植菌群中产广谱β-内酰胺酶（ESBL）大肠埃希菌的毒力因子：研究设计：采集产前母亲和产后新生儿的直肠拭子，并对其进行产ESBL大肠杆菌分析。然后对分离物进行全基因组测序：结果：在中国产科病房中，产广谱β-内酰胺酶（ESBL）大肠杆菌在产妇和新生儿中的定植率分别为18%（31/177）和5%（9/170）。与侵袭性大肠杆菌相比，粪便中产ESBL分离菌的毒力因子频率明显较低：结论：提供有关筛查结果的均衡信息以及对抗生素治疗策略进行风险评估至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.