The Safety and Efficacy of Left Atrial BOX Ablation in Persistent Atrial Fibrillation: A Meta-Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509316

Yang Li, Yin Xi, Wenyu Zhang, Jie Hao

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引用次数: 0

Abstract

Background: Circumferential pulmonary vein isolation (CPVI) has a high recurrence rate in managing persistent atrial fibrillation (AF). While some studies suggest that augmenting CPVI with additional left atrial BOX ablation can diminish this recurrence rate among patients with persistent AF, this approach remains controversial. This meta-analysis assesses the safety and efficacy of adjunctive left atrial BOX ablation in treating persistent atrial fibrillation.

Methods: We conducted a comprehensive literature search across China National Knowledge Infrastructure (CNKI), PubMed, Web of Science, and Cochrane Library, focusing on randomized controlled trials. The primary outcome was the recurrence rate of any atrial arrhythmias (AAs) within one-year post-treatment, with the secondary outcome being the frequency of adverse events related to the surgery.

Results: The combination of CPVI and left atrial BOX ablation did not lead to a significant reduction in the overall recurrence rate of atrial arrhythmias (risk ratios (RR) = 0.86, 95% confidence interval (CI) = 0.73-1.02, I² = 35%). However, subgroup analyses revealed that this therapeutic approach significantly decreased the recurrence rates of all atrial arrhythmias (RR = 0.67, 95% CI = 0.49-0.92, I² = 15%) and specifically atrial fibrillation (RR = 0.53, 95% CI = 0.37-0.77, I² = 0%) in patients with a left atrial diameter ≤44 mm. Notably, there was no significant increase in the incidence of procedure-related adverse events (RR = 1.04, 95% CI = 0.56-1.94, I² = 0%). However, the durations of both the ablation (mean difference (MD) = 19.77, 95% CI = 15.84-23.70, I² = 0%) and the overall procedure (MD = 15.64, 95% CI = 6.99-24.29, I² = 0%) were longer due to the additional ablation steps.

Conclusions: In patients with smaller left atrial diameters, augmenting CPVI with left atrial BOX ablation significantly lowers the recurrence rates of atrial arrhythmias and atrial fibrillation without elevating surgical risk levels.

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左心房 BOX 消融术治疗持续性心房颤动的安全性和有效性：元分析。

背景：环形肺静脉隔离术（CPVI）在治疗持续性房颤（AF）时复发率较高。虽然一些研究表明，在 CPVI 的基础上增加左心房 BOX 消融术可以降低持续性房颤患者的复发率，但这种方法仍存在争议。本荟萃分析评估了辅助左心房BOX消融术治疗持续性房颤的安全性和有效性：我们在中国国家知识基础设施（CNKI）、PubMed、Web of Science 和 Cochrane 图书馆进行了全面的文献检索，重点关注随机对照试验。主要结果是治疗后一年内任何房性心律失常（AAs）的复发率，次要结果是手术相关不良事件的发生频率：结果：CPVI和左心房BOX消融术的联合应用并未显著降低房性心律失常的总体复发率（风险比（RR）=0.86，95%置信区间（CI）=0.73-1.02，I2=35%）。然而，亚组分析显示，在左心房直径≤44 毫米的患者中，这种治疗方法显著降低了所有房性心律失常的复发率（RR = 0.67，95% CI = 0.49-0.92，I2 = 15%），特别是房颤的复发率（RR = 0.53，95% CI = 0.37-0.77，I2 = 0%）。值得注意的是，手术相关不良事件的发生率没有明显增加（RR = 1.04，95% CI = 0.56-1.94，I2 = 0%）。然而，由于增加了消融步骤，消融时间（平均差 (MD) = 19.77，95% CI = 15.84-23.70，I2 = 0%）和整个手术时间（MD = 15.64，95% CI = 6.99-24.29，I2 = 0%）都延长了：结论：对于左心房直径较小的患者，通过左心房BOX消融术增强CPVI可显著降低房性心律失常和心房颤动的复发率，且不会提高手术风险水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.