The Effect of Tolvaptan on Metabolism and Electrolyte Homeostasis in Patients with Heart Failure: A Systematic Review and Meta-Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-19 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509334

Yao Xiao, Yue Chen, Xianghao Zuo, Kadireya Mutalifu, Xiaoping Chen, Kai Liu

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引用次数: 0

Abstract

Background: This study aimed to investigate the effect of tolvaptan on metabolism and electrolyte homeostasis in patients with heart failure (HF).

Methods: Literature databases, such as PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, VIP, and WanFang Data, were systematically searched for relevant trials from inception to November 4, 2023. We used the fixed effect model to combine the effect sizes and used I² to test heterogeneity. Funnel plots were plotted to assess publication bias.

Results: 16 studies were eligible for further analysis. No significant differences were identified in the incidence of hyperuricemia between the tolvaptan group and the placebo group (odds ratio (OR) = 1.23, 95% confidence interval (CI) = 0.97 to 1.55, p = 0.09). Tolvaptan decreased the levels of blood uric acid compared to traditional diuretics (mean difference (MD) = -82.8, 95% CI = -96.48 to -69.13, p < 0.00001). There was no significant difference in hypernatremia (OR = 1.62, 95% CI = 0.66 to 3.96, p = 0.29) and hyperkalemia (OR = 1.17, 95% CI = 0.93 to 1.48, p = 0.18) between the tolvaptan and control groups.

Conclusions: Tolvaptan reduced the level of blood uric acid compared to conventional diuretics, and could be used as a substitute for traditional diuretics for HF patients with a high risk of gout.

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托伐普坦对心力衰竭患者代谢和电解质平衡的影响：系统综述与元分析》。

研究背景本研究旨在探讨托伐普坦对心力衰竭（HF）患者代谢和电解质平衡的影响：在PubMed、EMBASE、Cochrane图书馆、中国知网、VIP和万方数据等文献数据库中系统检索了从开始到2023年11月4日的相关试验。我们使用固定效应模型合并效应大小，并使用 I2 检验异质性。绘制漏斗图以评估发表偏倚：16项研究符合进一步分析的条件。托伐普坦组与安慰剂组的高尿酸血症发生率无明显差异（几率比（OR）= 1.23，95% 置信区间（CI）= 0.97 至 1.55，P = 0.09）。与传统利尿剂相比，托伐普坦能降低血尿酸水平（平均差 (MD) = -82.8，95% 置信区间 (CI) = -96.48 至 -69.13，p < 0.00001）。托伐普坦组和对照组在高钠血症（OR = 1.62，95% CI = 0.66 至 3.96，p = 0.29）和高钾血症（OR = 1.17，95% CI = 0.93 至 1.48，p = 0.18）方面没有明显差异：与传统利尿剂相比，托伐普坦能降低血尿酸水平，可作为痛风高风险高频患者传统利尿剂的替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.