Cytokine-Based Validation of the Inflammation-Based Risk Score in Patients with ST-Segment Elevation Myocardial Infarction.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Brianda Amezcua-Guerra, Luis M Amezcua-Castillo, Jazmín A Guerra-López, Kietseé Díaz-Domínguez, Héctor González-Pacheco, Luis M Amezcua-Guerra
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引用次数: 0

Abstract

This study aimed to validate an inflammation-based risk score in patients with ST-segment elevation myocardial infarction (STEMI) by examining their cytokine profiles. Upon admission, patients were evaluated for systemic inflammation using a risk score that assigned points based on specific biomarkers: 1 point for leukocyte count ≥9.3 × 10³ cells/μL, 2 points for high-sensitivity C-reactive protein (hsCRP) ≥13.0 mg/L, and 3 points for serum albumin ≤3.6 g/dL. Patients were categorized into three groups: no inflammation (0 points, n = 13), mild inflammation (1-2 points, n = 35), and severe inflammation (3-6 points, n = 26). Serum levels of 16 key cytokines were measured. Patients with higher risk scores showed elevated interleukin (IL)-6 levels (19.6 vs. 8.5 vs. 6.8 pg/mL; P = 0.021) and decreased interferon-γ-induced protein-10 (IP-10) levels (73.4 vs. 68.8 vs. 112.2 pg/mL; P = 0.011). IL-6 was positively correlated with hsCRP (ρ 0.307) and negatively correlated with albumin (ρ -0.298), while IP-10 was negatively correlated with leukocyte count (ρ -0.301). No other cytokines showed significant association with the risk score. Higher inflammation scores were also associated with an increased incidence of major adverse cardiovascular events, particularly acute heart failure. This study underscores the association between the inflammation-based risk score and cytokine levels, specifically IL-6 and IP-10, in patients with STEMI.

基于细胞因子的ST段抬高型心肌梗死患者炎症风险评分验证。
这项研究旨在通过检查ST段抬高型心肌梗死(STEMI)患者的细胞因子谱,验证基于炎症的风险评分。入院时,患者会接受全身炎症评估,评估采用风险评分法,根据特定的生物标志物进行打分:白细胞计数≥9.3×10³个/μL得1分,高敏C反应蛋白(hsCRP)≥13.0 mg/L得2分,血清白蛋白≤3.6 g/dL得3分。患者分为三组:无炎症(0 分,13 人)、轻度炎症(1-2 分,35 人)和重度炎症(3-6 分,26 人)。对血清中 16 种主要细胞因子的水平进行了测量。风险评分较高的患者白细胞介素 (IL)-6 水平升高(19.6 vs. 8.5 vs. 6.8 pg/mL;P = 0.021),干扰素-γ诱导蛋白-10 (IP-10) 水平降低(73.4 vs. 68.8 vs. 112.2 pg/mL;P = 0.011)。IL-6 与 hsCRP 呈正相关(ρ 0.307),与白蛋白呈负相关(ρ -0.298),而 IP-10 与白细胞计数呈负相关(ρ -0.301)。其他细胞因子均与风险评分无明显关联。炎症评分越高,主要不良心血管事件的发生率也越高,尤其是急性心力衰竭。这项研究强调了 STEMI 患者中基于炎症的风险评分与细胞因子水平(尤其是 IL-6 和 IP-10)之间的关联。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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