Association of vitamin B12 and vitamin D in T2DM patients in north Indian population

Advances in biomarker sciences and technology Pub Date : 2024-01-01 DOI:10.1016/j.abst.2024.09.001

Ishdeep Singh, Vivek Kumar Garg

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Abstract

Introduction

Diabetes mellitus, highly prevalent endocrine disorder and metformin is the most frequently recommended oral hypoglycemic agent (OHA).

Methods

We recruited 100 individuals who were taking OHA including metformin more than one year as cases and 40 healthy individuals as control. The patients were divided into three groups. The first group, Group I (n = 58) patients taking metformin, group II (n = 42) patients taking OHA other than metformin and group III (n = 40), taken as control group.

Results

In groups I, II, and III, a considerable number of patients experienced low levels of vitamin B12 i.e. 42 (72.41 %), 8 (19.05 %), and 14 (35 %) respectively. When comparing all groups, p-value was highly significant (p = 0.000). 35 (60.36 %), 13(30.95 %), and 15(37.5 %) patients had insufficient levels of vitamin D in groups I, II, III respectively. On comparing, p-value was highly significant (p = 0.007).

Conclusion

The study concluded that long-term metformin treatment causes insufficiency and deficiency of vitamin D and vitamin B12, respectively.

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北印度人群中 T2DM 患者体内维生素 B12 和维生素 D 的关系

方法我们招募了 100 名服用包括二甲双胍在内的口服降糖药超过一年的患者作为病例，40 名健康人作为对照。患者分为三组。第一组为服用二甲双胍的患者（58 人），第二组为服用二甲双胍以外的 OHA 的患者（42 人），第三组为对照组（40 人）。结果在第一组、第二组和第三组中，相当多的患者出现维生素 B12 含量低的情况，分别为 42 人（72.41%）、8 人（19.05%）和 14 人（35%）。比较所有组别，P 值非常显著（P = 0.000）。I 组、II 组和 III 组分别有 35（60.36 %）、13（30.95 %）和 15（37.5 %）名患者维生素 D 水平不足。结论该研究得出结论，长期二甲双胍治疗分别导致维生素 D 和维生素 B12 不足和缺乏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in biomarker sciences and technology Biotechnology, Clinical Biochemistry, Molecular Medicine, Public Health and Health Policy

自引率

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审稿时长

20 weeks