Frailty assessment in patients with Behçet's syndrome: A cross-sectional monocentric study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.reuma.2024.04.004

Hakan Apaydin , Serdar Can Güven , Rezan Koçak Ulucaköy , Hakan Babaoğlu , Esra Kayacan Erdoğan , Kevser Orhan , Berkan Armağan

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Abstract

Aims

Evidence evaluating the association between pre-frailty and frailty, and risk of adverse health outcomes in patients with Behçet's syndrome (BS) is limited in the literature. The aim of this study was to characterize the prevalence of frailty and associated factors in a single-centre cohort of patients with BS.

Methods

Based on the International Study Group's criteria, this was a monocentric cross-sectional study of BS patients. The Fried frailty criteria were used to define frailty. The Turkish version of the Behçet's Disease Current Activity Form was used to measure the disease activity of BS. Damage index was assessed with the Behçet's Syndrome Overall Damage Index.

Results

Forty-four patients were enrolled. According to Fried frailty criteria, patients were classified as 13.6% frail, 59% pre-frail, and 27.2% robust, respectively. Compared to pre-frail and robust patients, frail patients had higher levels of inflammatory markers at the time of diagnosis. CRP levels at time of diagnosis and at the last visit were higher in the frail group than in the pre-frail and robust groups (p = 0.039 and p = 0.023, respectively). When active drugs for BS were evaluated, systemic glucocorticoid (50%, p = 0.030) and cyclophosphamide (33.3%, p = 0.006) treatments were higher in the frail group.

Conclusions

Frailty and pre-frailty are commonly detected even in younger patients with BS. Inflammation can be described as potential determinants of frailty status.

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贝赫切特综合征患者的虚弱评估：横断面单中心研究

目的文献中评估贝赫切特综合征（BS）患者虚弱前和虚弱与不良健康后果风险之间关系的证据有限。本研究的目的是在一个单一中心的贝赫切特综合征患者队列中描述虚弱的发生率和相关因素。方法根据国际研究小组的标准，这是一项针对贝赫切特综合征患者的单中心横断面研究。弗里德虚弱标准用于定义虚弱。采用土耳其版的贝赫切特病活动度表来测量 BS 的疾病活动度。贝赫切特综合征总体损害指数用于评估损害指数。根据弗里德虚弱标准，患者中虚弱者占 13.6%，前期虚弱者占 59%，健壮者占 27.2%。与体弱前期和体格健壮的患者相比，体弱患者在确诊时的炎症标志物水平较高。体弱组在诊断时和最后一次就诊时的 CRP 水平均高于体弱前组和健壮组（分别为 p = 0.039 和 p = 0.023）。在评估治疗 BS 的活性药物时，体弱组使用全身糖皮质激素（50%，p = 0.030）和环磷酰胺（33.3%，p = 0.006）治疗的比例更高。炎症可被视为虚弱状态的潜在决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.