Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering.

IF 3 4区医学 Q2 NEUROSCIENCES

Purinergic Signalling Pub Date : 2024-10-01 DOI:10.1007/s11302-024-10052-9

Jianchen Fan, Zhihua Gao

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引用次数: 0

Abstract

The glymphatic system is critical for brain homeostasis by eliminating metabolic waste, whose disturbance contributes to the accumulation of pathogenic proteins in neurodegenerative diseases. Promoting glymphatic clearance is a potential and attractive strategy for several brain disorders, including neurodegenerative diseases. Previous studies have uncovered that 40 Hz flickering augmented glymphatic flow and facilitated sleep (Zhou et al. in Cell Res 34:214-231, 2024) since sleep drives waste clearance via glymphatic flow (Xie et al. in Science 342:373-377, 2013). However, it remains unclear whether 40 Hz light flickering directly increased glymphatic flow or indirectly by promoting sleep. A recent article published in Cell Discovery by Chen et al. (Sun et al. in Cell Discov 10:81, 2024) revealed that 40 Hz light flickering facilitated glymphatic flow, by promoting the polarization of astrocytic aquaporin-4 (AQP4) and vasomotion through upregulated adenosine-A_2A receptor (A_2AR) signaling, independent of sleep. These findings suggest that 40 Hz light flickering may be used as a non-invasive approach to control the function of the glymphatic-lymphatic system, to help remove metabolic waste in the brain, thereby presenting a potential strategy for neurodegenerative disease treatment.

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促进淋巴流动：使用 40 Hz 灯光闪烁的非侵入性策略。

甘油系统通过清除代谢废物对大脑的平衡至关重要，而代谢废物的紊乱会导致神经退行性疾病中致病蛋白质的积累。对于包括神经退行性疾病在内的多种脑部疾病，促进甘油清除是一种具有吸引力的潜在策略。先前的研究发现，40 赫兹的闪烁能增强甘液流并促进睡眠（Zhou 等，发表于《细胞研究》34:214-231，2024 年），因为睡眠能通过甘液流促进废物清除（Xie 等，发表于《科学》342:373-377，2013 年）。然而，目前仍不清楚40赫兹的灯光闪烁是直接增加了脑浆流动，还是通过促进睡眠间接增加了脑浆流动。最近，Chen等人发表在《细胞发现》（Cell Discovery）上的一篇文章（Sun等人，发表于《细胞发现》10:81, 2024）揭示，40赫兹光闪烁通过上调腺苷-A2A受体（A2AR）信号，促进星形胶质细胞水光素-4（AQP4）的极化和血管运动，从而促进甘液流动，与睡眠无关。这些研究结果表明，40 赫兹的灯光闪烁可作为一种非侵入性方法来控制甘液-淋巴系统的功能，帮助清除大脑中的代谢废物，从而为神经退行性疾病的治疗提供一种潜在的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Purinergic Signalling 医学-神经科学

CiteScore

6.60

自引率

17.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.