Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database.

IF 1.6 Q4 ONCOLOGY

Journal of Gastrointestinal Cancer Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI:10.1007/s12029-024-01096-6

Yusuf Nawras, Nooraldin Merza, Katie Beier, Aya Dakroub, Hasan Al-Obaidi, Ahmed Dheyaa Al-Obaidi, Hajera Amatul-Raheem, Eshak Bahbah, Tony Varughese, Jerome Hosny, Mona Hassan, Abdallah Kobeissy

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引用次数: 0

Abstract

Background: The mortality rates of early-onset colorectal cancer (EOCRC) have surged globally over the past two decades. While the underlying reasons remain largely unknown, understanding its epidemiology is crucial to address this escalating trend. This study aimed to identify disparities potentially influencing these rates, enhancing risk assessment tools, and highlighting areas necessitating further research.

Methods: Using the CDC Wide-Ranging Online Data for Epidemiologic Research (WONDER) database, this study assessed EOCRC mortality data from 2012 to 2020. Individuals under 50 years who succumbed to EOCRC were identified through the International Classification of Diseases, Tenth Revision (ICD-10) codes. Data interpretation and representation were performed using R 4.2.2 software.

Results: Between 2012 and 2020, EOCRC mortality rates fluctuated marginally between 1.7 and 1.8 per 100,000. Male mortality rates increased from 1.9 to 2.0 per 100,000, while female rates varied between 1.5 and 1.6 per 100,000. Significant variations were observed across age groups, with the 40-49 years category experiencing an increase from 6.34 (2012) to 6.94 (2020) per 100,000. Racial category-based data revealed the highest mortality rates among African Americans. Geographically, Mississippi and Alabama exhibited elevated mortality rates. Age-adjusted mortality rate (AAMR) assessments indicated a marked decline for both genders from 2012 to 2020, with consistently higher rates for men.

Conclusion: The findings highlight the evolving landscape of EOCRC mortality, revealing significant gender, age, and racial disparities. These results underscore the urgent need for tailored health strategies and intensified research efforts targeting these disparities.

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美国早期结直肠癌种族和性别差异的时间趋势：CDC WONDER 数据库分析》。

背景：过去二十年来，早发结直肠癌（EOCRC）的死亡率在全球激增。虽然其根本原因在很大程度上仍不为人所知，但了解其流行病学对于应对这一不断升级的趋势至关重要。本研究旨在确定可能影响这些发病率的差异，加强风险评估工具，并强调需要进一步研究的领域：本研究使用美国疾病预防控制中心的广泛流行病学研究在线数据（WONDER）数据库，评估了2012年至2020年的EOCRC死亡率数据。通过国际疾病分类第十次修订版（ICD-10）代码确定了50岁以下死于EOCRC的个体。数据解释和表示使用 R 4.2.2 软件：结果：2012 年至 2020 年间，EOCRC 死亡率在每 10 万人 1.7 至 1.8 之间小幅波动。男性死亡率从每 10 万人 1.9 例上升至 2.0 例，女性死亡率则在每 10 万人 1.5 例和 1.6 例之间波动。不同年龄组的死亡率差异显著，40-49 岁年龄组的死亡率从每 10 万人 6.34 例（2012 年）上升到每 10 万人 6.94 例（2020 年）。基于种族类别的数据显示，非裔美国人的死亡率最高。从地域上看，密西西比州和阿拉巴马州的死亡率较高。年龄调整死亡率（AAMR）评估显示，从 2012 年到 2020 年，男女死亡率均显著下降，男性死亡率一直较高：研究结果突显了 EOCRC 死亡率不断变化的状况，揭示了显著的性别、年龄和种族差异。这些结果突出表明，迫切需要针对这些差异制定有针对性的健康策略并加强研究工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastrointestinal Cancer ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

121

期刊介绍： The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.