Prognostic significance of electrophysiological study in drug-induced type-1 Brugada syndrome: a brief systematic review.

IF 2.9 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-13 DOI:10.2459/JCM.0000000000001665

Giuseppe Mascia, Josep Brugada, Luca Barca, Stefano Benenati, Roberta Della Bona, Antonio Scarà, Vincenzo Russo, Elena Arbelo, Paolo Di Donna, Italo Porto

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引用次数: 0

Abstract

Background: Risk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations.

Methods: A complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group.

Results: Among 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status.

Conclusion: In long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification.

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药物诱发 1 型 Brugada 综合征电生理学研究的预后意义：简要系统综述。

背景：对药物诱发的1型Brugada综合征（BrS）患者进行风险分层具有挑战性。电生理学研究（EPS）的作用存在争议，因为大多数药物诱发的 1 型 BrS 患者不会根据最新建议进行研究：方法：进行了一次完整的系统性文献检索，以评估 EPS 在该人群中的作用。结果：在 1318 名药物诱发的 1 型 BrS 患者中，EPS 阳性组、EPS 阴性组和 EPS 阳性组的比例为 1:1，而 EPS 阳性组的比例为 1:1：结果：在1318名药物诱发的1型BRS患者中，平均随访5.1年，考虑到症状状况，各组间心律失常事件发生率无明显差异（I2=45%，亚组差异P=0.10）：结论：在药物诱发的 1 型 BrS 患者的长期随访中，EPS 似乎无助于预后分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Medicine 医学-心血管系统

CiteScore

3.90

自引率

26.70%

发文量

189

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Medicine is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.