Preserving Fertility in People With Rheumatic Diseases.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Molly Leavitt, Amanda Adeleye, Cuoghi Edens
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Abstract

Abstract: Rheumatology patients historically were told they "can't" or "shouldn't" become pregnant. Improved rheumatic diagnostics and treatments have led to decreased morbidity and mortality and increased quality of life resulting in an opportunity to focus on fertility and its preservation. In the same vein as rheumatic disease care, assisted reproductive technology (ART), which includes freezing of egg and sperm as well as in vitro fertilization, has made considerable strides in the recent past. ART is safe for those with rheumatic diseases and has comparable outcomes to the general public, but may take additional effort due to optimal timing, rheumatic medications, and other nuances. In a specialty that treats chronic inflammatory diagnoses using teratogens and gonadotoxins, it is important to address family building desires with patients so their goals can be met.Rheumatologists have little knowledge of ART and how it impacts or applies to their patients; however, patients want their rheumatologist to be the source of knowledge for this information (Arthritis Rheumatol. 2022;74:suppl 9). Many barriers to ART exist and will be explored, with the financial burden being paramount (Glob J Health Sci. 6;1:181-191). Future efforts to examine the future fertility of rheumatology patients in an era of biologics and "treat-to-target" are needed to better understand who would most benefit from this costly and not without risk medical treatment. Given the changing landscape of financial support for ART due to insurance mandates, rheumatologists should not modify counseling based on the anticipated ability of patients to afford care. Preservation should also be broached with patients without partners and those from the LGBTQAI+ community. In addition to expanding the education of rheumatologists regarding this topic and its incorporation into clinical care, advocacy for ART access and insurance coverage is a much-needed future direction.

保护风湿病患者的生育能力。
摘要:风湿病患者历来被告知 "不能 "或 "不应该 "怀孕。风湿病诊断和治疗方法的改进降低了发病率和死亡率,提高了生活质量,从而使人们有机会关注生育能力及其保护。与风湿病治疗相同,辅助生殖技术(ART),包括冷冻卵子和精子以及体外受精,在最近也取得了长足的进步。辅助生殖技术对风湿病患者是安全的,其结果也与普通人相当,但由于最佳时机、风湿病药物和其他细微差别,可能需要付出更多努力。风湿免疫科医生对 ART 及其对患者的影响和应用知之甚少;然而,患者希望他们的风湿免疫科医生成为这方面知识的来源(Arthritis Rheumatol.)抗逆转录病毒疗法存在许多障碍,我们将对这些障碍进行探讨,其中最主要的障碍是经济负担(《全球健康科学》6;1:181-191)。在使用生物制剂和 "靶向治疗 "的时代,需要对风湿病患者未来的生育能力进行研究,以更好地了解谁最能从这种昂贵且不无风险的医疗中获益。由于保险规定,抗逆转录病毒疗法的经济支持不断变化,因此风湿免疫科医生不应根据患者的预期负担能力来修改咨询内容。对于没有伴侣的患者和来自 LGBTQAI+ 群体的患者,也应提出保留治疗方案的建议。除了扩大风湿免疫科医生对这一主题的教育并将其纳入临床护理外,倡导抗逆转录病毒疗法的可及性和保险覆盖面也是亟待解决的未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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