Relationship between magnesium dosage and the preventive effect on cisplatin-induced nephrotoxicity: meta-analysis and meta-regression analysis.

IF 2.4 3区医学 Q3 ONCOLOGY

International Journal of Clinical Oncology Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI:10.1007/s10147-024-02629-6

Keisuke Okamoto, Yoshitaka Saito, Atsushi Yamaguchi, Katsuya Narumi, Masaki Kobayashi

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引用次数: 0

Abstract

Background: Cisplatin (CDDP) is an anticancer drug used to treat several types of cancer. CDDP-induced nephrotoxicity (CIN) is a serious adverse effect of CDDP treatment. Although magnesium sulfate (Mg) premedication has been proven to prevent CIN, the relationship between Mg dosage and its preventive effects on CIN are unknown. Therefore, we have evaluated this relationship using meta-analysis and meta-regression analysis to optimize cancer chemotherapies, including CDDP.

Methods: We selected candidate studies, generated a forest plot to evaluate the preventive effects of Mg on CIN, and performed subgroup analyses. Moreover, a meta-regression analysis was conducted to reveal the relationship between Mg dosage and its preventive effects on CIN.

Results: We identified 17 related studies and the total odds ratio (OR) of Mg premedication on CIN was 0.26 and the 95% confidence interval (95% CI) was 0.17-0.41 (p < 0.00001) although funnel plot suggested asymmetry. In subgroup analysis by forest plot, total OR with 95% CI of low Mg dosage administration (less than 10 mEq) and high Mg dosage administration (10 mEq or higher) was 0.35 (0.16-0.77, p = 0.0169) and 0.12 (0.07-0.21, p < 0.0001), respectively. In addition, meta-regression analysis was performed on Mg dosage and the OR of related studies, indicating a relationship between Mg dosage and OR (p = 0.0349).

Conclusion: This study has revealed that premedication with Mg prevented CIN in a dose-dependent manner.

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镁剂量与顺铂诱导的肾毒性预防效果之间的关系：荟萃分析和荟萃回归分析。

背景：顺铂（CDDP）是一种用于治疗多种癌症的抗癌药物。CDDP 诱导的肾毒性（CIN）是 CDDP 治疗的一种严重不良反应。虽然硫酸镁（Mg）的预处理已被证实可以预防 CIN，但 Mg 剂量与其对 CIN 的预防效果之间的关系尚不清楚。因此，我们利用荟萃分析和荟萃回归分析评估了这种关系，以优化包括 CDDP 在内的癌症化疗：我们选择了候选研究，绘制了森林图以评估镁对 CIN 的预防作用，并进行了亚组分析。此外，我们还进行了元回归分析，以揭示镁剂量与其对 CIN 的预防作用之间的关系：我们确定了 17 项相关研究，镁预处理对 CIN 的总几率比（OR）为 0.26，95% 置信区间（95% CI）为 0.17-0.41（P 结论：该研究揭示了镁预处理对 CIN 的预防作用：本研究揭示了镁预处理对 CIN 的预防作用呈剂量依赖性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Oncology 医学-肿瘤学

CiteScore

6.80

自引率

3.00%

发文量

175

审稿时长

2 months

期刊介绍： The International Journal of Clinical Oncology (IJCO) welcomes original research papers on all aspects of clinical oncology that report the results of novel and timely investigations. Reports on clinical trials are encouraged. Experimental studies will also be accepted if they have obvious relevance to clinical oncology. Membership in the Japan Society of Clinical Oncology is not a prerequisite for submission to the journal. Papers are received on the understanding that: their contents have not been published in whole or in part elsewhere; that they are subject to peer review by at least two referees and the Editors, and to editorial revision of the language and contents; and that the Editors are responsible for their acceptance, rejection, and order of publication.