Probiotic therapy as a promising strategy for gestational diabetes mellitus management.

IF 3.6 3区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Expert Opinion on Biological Therapy Pub Date : 2024-09-30 DOI:10.1080/14712598.2024.2409880

Deborah Emanuelle de Albuquerque Lemos, José Luiz de Brito Alves, Evandro Leite de Souza

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Abstract

Introduction: Gestational diabetes mellitus (GDM) has become the most common pregnancy medical complication, and its prevalence has increased in recent years. The GDM treatment primarily relies on adopting healthy eating habits, physical exercise, and insulin therapy. However, using probiotics to modulate the gut microbiota has been the subject of clinical trials as a promising therapeutic strategy for GDM management.

Areas covered: Due to the adverse effects of gut dysbiosis in women with GDM, strategies targeting the gut microbiota to mitigate hyperglycemia, low-grade inflammation, and adverse pregnancy outcomes have been explored. Probiotic supplementation may improve glucose metabolism, lipid profile, oxidative stress, inflammation, and blood pressure in women with GDM. Furthermore, decreased fasting blood glucose, insulin resistance, and inflammatory markers, such as TNF-α and CRP, as well as increased total antioxidant capacity, lipid profile modulation, and improved blood pressure in women with GDM, are some of the important results reported in the available literature.

Expert opinion: To fill the knowledge gap, further studies are needed focusing on modulating gut microbiota composition and metabolic activity and their systemic repercussions in GDM.

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益生菌疗法是治疗妊娠糖尿病的有效策略。

简介妊娠期糖尿病（GDM）已成为最常见的妊娠并发症，近年来其发病率呈上升趋势。GDM 的治疗主要依靠养成健康的饮食习惯、体育锻炼和胰岛素治疗。然而，使用益生菌调节肠道微生物群已成为临床试验的主题，是治疗 GDM 的一种很有前景的治疗策略：由于肠道菌群失调对 GDM 妇女的不利影响，人们探索了针对肠道微生物群的策略，以缓解高血糖、低度炎症和不良妊娠结局。补充益生菌可改善 GDM 妇女的糖代谢、血脂、氧化应激、炎症和血压。此外，现有文献报道的一些重要结果还包括，GDM 妇女的空腹血糖、胰岛素抵抗、TNF-α 和 CRP 等炎症指标降低，总抗氧化能力提高，血脂状况得到调节，血压得到改善：专家意见：为了填补知识空白，需要进一步研究肠道微生物群的组成和代谢活动及其对 GDM 的全身影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Biological Therapy 医学-生物工程与应用微生物

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.