Relationship between migraine and epilepsy in a large population-based cohort: The HUNT Study.

IF 4.5 2区医学 Q1 CLINICAL NEUROLOGY

European Journal of Neurology Pub Date : 2024-09-27 DOI:10.1111/ene.16496

Helene Engstrand, Eline Revdal, Maria Bengtson Argren, Knut Hagen, John-Anker Zwart, Eylert Brodtkorb, Bendik Slagsvold Winsvold

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引用次数: 0

Abstract

Background and purpose: Several studies have reported substantial comorbidity between epilepsy and migraine. Most of these were based on clinical cohorts or used unvalidated diagnostic instruments. Our study re-examined this association in a large general population cohort using validated diagnoses for both disorders.

Methods: A total of 65,407 participants (≥20 years old) from HUNT (the Trøndelag Health Study) were classified for migraine and nonmigraine headache using a validated questionnaire. Medical record review was used to validate and classify epilepsy in 364 participants (cases), who were compared with 63,298 participants without epilepsy (controls). The association between epilepsy and migraine was analysed using logistic regression adjusted for sex and age.

Results: Patients with epilepsy had no increased prevalence of migraine (odds ratio [OR] = 0.95, 95% confidence interval [CI] = 0.68-1.33) or nonmigraine headache (OR = 1.18, 95% CI = 0.93-1.50) compared to controls. When stratified by headache frequency, epilepsy was associated with a higher prevalence of migraine with highly frequent headache (≥7 days/month; OR = 1.73, 95% CI = 1.08-2.78).

Conclusions: Migraine was equally common in people with and without epilepsy. Patients with epilepsy who suffered from migraine were more prone to having highly frequent migraine.

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基于人口的大型队列中偏头痛与癫痫之间的关系：HUNT 研究。

背景和目的：多项研究报告了癫痫和偏头痛之间的大量合并症。这些研究大多基于临床队列或使用未经验证的诊断工具。我们的研究使用对这两种疾病的有效诊断，在一个大型普通人群队列中重新检验了这种关联：方法：使用经过验证的问卷对 HUNT（特伦德拉格健康研究）的 65,407 名参与者（≥ 20 岁）进行偏头痛和非偏头痛分类。通过病历审查对 364 名参与者（病例）的癫痫进行了验证和分类，并与 63,298 名无癫痫参与者（对照）进行了比较。采用逻辑回归分析了癫痫与偏头痛之间的关系，并对性别和年龄进行了调整：结果：与对照组相比，癫痫患者的偏头痛（几率比 [OR] = 0.95，95% 置信区间 [CI] = 0.68-1.33）或非偏头痛（OR = 1.18，95% CI = 0.93-1.50）发病率没有增加。如果按头痛频率分层，癫痫与偏头痛发病率较高且头痛频率较高（≥7 天/月；OR = 1.73，95% CI = 1.08-2.78）相关：偏头痛在癫痫患者和非癫痫患者中同样常见。结论：偏头痛在癫痫患者和非癫痫患者中同样常见，而患有偏头痛的癫痫患者更容易患上高频率偏头痛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Neurology 医学-临床神经学

CiteScore

9.70

自引率

2.00%

发文量

418

审稿时长

1 months

期刊介绍： The European Journal of Neurology is the official journal of the European Academy of Neurology and covers all areas of clinical and basic research in neurology, including pre-clinical research of immediate translational value for new potential treatments. Emphasis is placed on major diseases of large clinical and socio-economic importance (dementia, stroke, epilepsy, headache, multiple sclerosis, movement disorders, and infectious diseases).