Drug metabolism and transport mediated the hepatotoxicity of Pleuropterus multiflorus root: a review.

IF 3.4 2区 医学 Q2 PHARMACOLOGY & PHARMACY
Drug Metabolism Reviews Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1080/03602532.2024.2405163
Zhaoquan Wu, Dangang Shangguan, Qi Huang, Yi-Kun Wang
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引用次数: 0

Abstract

Pleuropterus multiflorus root (PMR, Polygoni Multiflori Radix) is an herbal medicine widely used in East Asia, particularly China. However, the potential hepatotoxicity has hindered its rational and safe application of PMR in clinical practice. Recently, the hepatotoxic study of PMR have made great progress, especially drug metabolism and transport-mediated liver injury. In this review, we summarized the advancement of drug metabolism and transport regluated hepatic injury of PMR, pointed out the key role of drug metabolizing enzymes and transporters in regulating hepatic injury of PMR, and emphasized the main hepatotoxic substances, toxicity promoter, and hepatic toxic substance-toxicity promoter interactions in PMR. On this basis, the clinical prospect of preventing and treating hepatic injury of PMR from the perspective of metabolism and transporter was discussed, to provide a useful reference and theoretical basis for the prevention and treatment of hepatic injury of PMR.

药物代谢和转运介导的多花蛇床子根肝毒性:综述。
何首乌(PMR,Polygoni Multiflori Radix)是一种在东亚,尤其是中国广泛使用的草药。然而,其潜在的肝脏毒性阻碍了其在临床实践中的合理安全应用。近来,原植物药的肝毒性研究取得了重大进展,尤其是药物代谢和转运介导的肝损伤。在这篇综述中,我们总结了药物代谢和转运调节原发性肝损伤的研究进展,指出了药物代谢酶和转运体在调节原发性肝损伤中的关键作用,并强调了原发性肝损伤中的主要肝毒性物质、毒性促进因子以及肝毒性物质与毒性促进因子之间的相互作用。在此基础上,从代谢和转运体的角度探讨了预防和治疗 PMR 肝损伤的临床前景,为预防和治疗 PMR 肝损伤提供了有益的参考和理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Drug Metabolism Reviews
Drug Metabolism Reviews 医学-药学
CiteScore
11.10
自引率
1.70%
发文量
21
审稿时长
1 months
期刊介绍: Drug Metabolism Reviews consistently provides critically needed reviews of an impressive array of drug metabolism research-covering established, new, and potential drugs; environmentally toxic chemicals; absorption; metabolism and excretion; and enzymology of all living species. Additionally, the journal offers new hypotheses of interest to diverse groups of medical professionals including pharmacologists, toxicologists, chemists, microbiologists, pharmacokineticists, immunologists, mass spectroscopists, as well as enzymologists working in xenobiotic biotransformation.
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