HIP: a method for high-dimensional multi-view data integration and prediction accounting for subgroup heterogeneity.

IF 6.8 2区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS
Jessica Butts, Leif Verace, Christine Wendt, Russel P Bowler, Craig P Hersh, Qi Long, Lynn Eberly, Sandra E Safo
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引用次数: 0

Abstract

Epidemiologic and genetic studies in many complex diseases suggest subgroup disparities (e.g. by sex, race) in disease course and patient outcomes. We consider this from the standpoint of integrative analysis where we combine information from different views (e.g. genomics, proteomics, clinical data). Existing integrative analysis methods ignore the heterogeneity in subgroups, and stacking the views and accounting for subgroup heterogeneity does not model the association among the views. We propose Heterogeneity in Integration and Prediction (HIP), a statistical approach for joint association and prediction that leverages the strengths in each view to identify molecular signatures that are shared by and specific to a subgroup. We apply HIP to proteomics and gene expression data pertaining to chronic obstructive pulmonary disease (COPD) to identify proteins and genes shared by, and unique to, males and females, contributing to the variation in COPD, measured by airway wall thickness. Our COPD findings have identified proteins, genes, and pathways that are common across and specific to males and females, some implicated in COPD, while others could lead to new insights into sex differences in COPD mechanisms. HIP accounts for subgroup heterogeneity in multi-view data, ranks variables based on importance, is applicable to univariate or multivariate continuous outcomes, and incorporates covariate adjustment. With the efficient algorithms implemented using PyTorch, this method has many potential scientific applications and could enhance multiomics research in health disparities. HIP is available at https://github.com/lasandrall/HIP, a video tutorial at https://youtu.be/O6E2OLmeMDo and a Shiny Application at https://multi-viewlearn.shinyapps.io/HIP_ShinyApp/ for users with limited programming experience.

HIP:一种考虑亚组异质性的高维多视角数据整合与预测方法。
许多复杂疾病的流行病学和遗传学研究表明,亚群体(如性别、种族)在疾病过程和患者预后方面存在差异。我们从综合分析的角度来考虑这个问题,将来自不同视角(如基因组学、蛋白质组学、临床数据)的信息结合起来。现有的整合分析方法忽略了亚组的异质性,而堆叠视图和考虑亚组异质性并不能模拟视图之间的关联。我们提出了 "整合与预测中的异质性"(HIP),这是一种用于联合关联与预测的统计方法,它利用每个视图的优势来识别亚组共享和特异的分子特征。我们将 HIP 应用于与慢性阻塞性肺病(COPD)有关的蛋白质组学和基因表达数据,以确定男性和女性共有的和特有的蛋白质和基因,这些蛋白质和基因导致了慢性阻塞性肺病(通过气道壁厚度测量)的变异。我们的慢性阻塞性肺病研究发现了男性和女性共有的和特有的蛋白质、基因和通路,其中一些与慢性阻塞性肺病有关,而另一些则可能导致对慢性阻塞性肺病性别差异机制的新认识。HIP 考虑了多视图数据中的亚组异质性,根据重要性对变量进行排序,适用于单变量或多变量连续结果,并结合了协变量调整。通过使用 PyTorch 实现的高效算法,该方法具有许多潜在的科学应用价值,并能加强健康差异方面的多组学研究。HIP 可从 https://github.com/lasandrall/HIP 获取,视频教程可从 https://youtu.be/O6E2OLmeMDo 获取,Shiny 应用程序可从 https://multi-viewlearn.shinyapps.io/HIP_ShinyApp/ 获取,供编程经验有限的用户使用。
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来源期刊
Briefings in bioinformatics
Briefings in bioinformatics 生物-生化研究方法
CiteScore
13.20
自引率
13.70%
发文量
549
审稿时长
6 months
期刊介绍: Briefings in Bioinformatics is an international journal serving as a platform for researchers and educators in the life sciences. It also appeals to mathematicians, statisticians, and computer scientists applying their expertise to biological challenges. The journal focuses on reviews tailored for users of databases and analytical tools in contemporary genetics, molecular and systems biology. It stands out by offering practical assistance and guidance to non-specialists in computerized methodologies. Covering a wide range from introductory concepts to specific protocols and analyses, the papers address bacterial, plant, fungal, animal, and human data. The journal's detailed subject areas include genetic studies of phenotypes and genotypes, mapping, DNA sequencing, expression profiling, gene expression studies, microarrays, alignment methods, protein profiles and HMMs, lipids, metabolic and signaling pathways, structure determination and function prediction, phylogenetic studies, and education and training.
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