Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2024-10-01 DOI:10.21873/anticanres.17262

Po-Ju Lin, Yu-Cheng Kuo, Po-Wei Hu, Wei-Lung Chen, Shih-Chieh Chang, Fei-Ting Hsu, Jeng-Yuan Wu, Jiann-Hwa Chen

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引用次数: 0

Abstract

Background/aim: Non-small cell lung cancer is known for its rapid growth and immune evasion, demanding effective therapies targeting both tumor cells and the microenvironment. Magnolol has shown promising anti-tumor effects in various cancers.

Materials and methods: CL1-5-F4-bearing mice were divided into control, 40 mg/kg, and 60 mg/kg magnolol groups, once tumors reached 100 mm³ Tumor growth and body weight were monitored biweekly, and after 13 days, mice were euthanized for tumor and organ collection for subsequent staining. Histopathology and serum biochemistry assessed organ toxicity.

Results: Magnolol dose-dependently suppressed NSCLC progression, with no pathology alterations observed in normal organs. Magnolol-induced apoptosis and cell cycle arrest, evidenced by increased cleaved caspase-3 and decreased cyclin D1/CDK4 levels. It also down-regulated VEGF, FOXP3, and IDO-1 in tumors, implicating tumor microenvironment modulation.

Conclusion: Magnolol exhibits significant antitumor effects in NSCLC by inducing apoptosis, inhibiting proliferation, and modulating the tumor microenvironment. These results support further investigation of magnolol as a therapeutic adjuvant to enhance NSCLC treatment outcomes.

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木兰醇诱导非小细胞肺癌异种移植模型的细胞凋亡并抑制免疫逃避

背景/目的：非小细胞肺癌以其快速生长和免疫逃避而闻名，需要针对肿瘤细胞和微环境的有效疗法。木兰醇在多种癌症中显示出良好的抗肿瘤效果：将CL1-5-F4小鼠分为对照组、40毫克/千克和60毫克/千克马格诺洛尔组，每两周监测一次肿瘤生长情况和体重，13天后安乐死，收集肿瘤和器官进行后续染色。组织病理学和血清生物化学评估器官毒性：结果：木酚醇剂量依赖性地抑制了NSCLC的进展，正常器官未见病理改变。木兰醇诱导细胞凋亡和细胞周期停滞，表现为裂解的caspase-3增加和细胞周期蛋白D1/CDK4水平降低。它还能下调肿瘤中的血管内皮生长因子、FOXP3和IDO-1，这与肿瘤微环境调节有关：结论：木酚醇通过诱导凋亡、抑制增殖和调节肿瘤微环境对 NSCLC 具有明显的抗肿瘤作用。这些结果支持将马格诺洛尔作为辅助治疗药物进行进一步研究，以提高 NSCLC 的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.