Clinical Significance of Granzyme B Gene Expression in Pathological Stage II/III Gastric Cancer After Curative Gastrectomy.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2024-10-01 DOI:10.21873/anticanres.17282

Takashi Oshima, Itaru Hashimoto, Yukihiko Hiroshima, Yayoi Kimura, Mie Tanabe, Yuta Nakayama, Shinsuke Nagasawa, Kyohei Kanematsu, Toru Aoyama, Takanobu Yamada, Takashi Ogata, Yohei Miyagi

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引用次数: 0

Abstract

Background/aim: Granzyme B (GZMB) is mainly produced by natural killer (NK) cells and activated CD8-positive T cells to induce tumor cell apoptosis. We analyzed the significance of GZMB expression in gastric cancer (GC) tissues from patients with pathological (p)Stage II/III GC after curative resection.

Patients and methods: Patients with pStage II/III GC who received curative resection (n=253) were included and the expression levels of GZMB in GC tissues and in the adjacent normal mucosa were measured using quantitative real-time polymerase chain reaction. The expression levels in GC tissues and clinicopathological features and overall survival (OS) were compared in these patients.

Results: GZMB expression levels were significantly higher in GC tissues than in the adjacent normal mucosa. GZMB expression levels in GC tissues were not associated with any clinicopathological features. The 5-year OS rate in the high-GZMB expression group was significantly better than that in the low-expression group (5-year survival rate 72.0% vs. 55.7%; p=0.009). Furthermore, on multivariate analysis, high-GZMB expression was an independent factor for better OS (hazard ratio=0.652; 95% confidence interval=0.432-0.987; p=0.043).

Conclusion: In patients with locally advanced GC after curative resection, GZMB expression in GC tissue may be a useful prognostic marker.

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治愈性胃切除术后病理 II/III 期胃癌中 Granzyme B 基因表达的临床意义

背景/目的：颗粒酶B（GZMB）主要由自然杀伤细胞（NK）和活化的CD8阳性T细胞产生，诱导肿瘤细胞凋亡。我们分析了治愈性切除术后病理（p）II/III期胃癌（GC）患者组织中GZMB表达的意义：纳入接受根治性切除术的p期II/III GC患者（n=253），采用定量实时聚合酶链反应法测定GZMB在GC组织和邻近正常黏膜中的表达水平。结果发现，GZMB在GC组织中的表达水平明显高于在邻近正常粘膜中的表达水平：结果：GC组织中GZMB的表达水平明显高于邻近的正常黏膜。GC组织中GZMB的表达水平与任何临床病理特征无关。GZMB高表达组的5年生存率明显优于低表达组（5年生存率为72.0% vs. 55.7%; p=0.009）。此外，在多变量分析中，GZMB高表达是改善OS的独立因素（危险比=0.652；95%置信区间=0.432-0.987；P=0.043）：结论：对于根治性切除术后的局部晚期GC患者，GC组织中GZMB的表达可能是一个有用的预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.