Prokinetic agents in adult intensive care unit patients (PATIENCE)-An international inception cohort study protocol.

IF 1.9 4区 医学 Q2 ANESTHESIOLOGY
Acta Anaesthesiologica Scandinavica Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI:10.1111/aas.14534
Vera Crone, Morten Hylander Møller, Anders Perner, Waleed Alhazzani, Anders Granholm, Laura Rindom Krogsgaard, Abdulrahman Al-Fares, Johanna Hästbacka, Marlies Ostermann, Carmen A Pfortmueller, Richard Ferrer, Annika Reintam Blaser, Martin I Sigurdsson, Olof Wall, Eric Keus, Wojciech Szczeklik, Mette Krag
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引用次数: 0

Abstract

Background: Feeding intolerance is common in critically ill patients and can lead to malnutrition. Prokinetic agents may be used to enhance the uptake of nutrition. However, the evidence on the effectiveness and safety of prokinetic agents is sparse, and there is a lack of data on their use in intensive care units (ICU).

Methods: We will conduct an international 14-day inception cohort study of 1000 acutely admitted adult ICU patients. Data will be collected from ICU admission and daily during ICU stay for up to 90 days. The primary outcome will be the proportion of ICU patients who receive prokinetic agents. Secondary outcomes include mortality, days alive without life support, days alive out of ICU, days alive out of hospital (all within 90 days) and the number of patients with one or more serious adverse events.

Results: We will present data on the use of prokinetic agents descriptively and use Cox regressions with death and ICU discharge as competing events to evaluate the association between patient characteristics and the use of prokinetic agents. We will use extended Cox models with time-varying covariates and linear regression models to assess the associations between the use of prokinetic agents and the secondary outcomes.

Conclusion: The outlined international cohort study will provide valuable epidemiological data on the use of prokinetic agents in adult, acutely admitted ICU patients.

成人重症监护室患者使用促动力药(PATIENCE)--国际初始队列研究方案。
背景:喂养不耐受在重症患者中很常见,可导致营养不良。促激剂可用于促进营养吸收。然而,有关促动力药的有效性和安全性的证据并不多,而且缺乏在重症监护病房(ICU)使用促动力药的数据:我们将对 1000 名重症监护室急诊成人患者进行为期 14 天的国际起始队列研究。我们将对 1000 名急诊入住重症监护室的成人患者进行为期 14 天的国际起始队列研究,并将在重症监护室入院时和重症监护室住院 90 天内每天收集数据。主要结果是接受促动力药物治疗的 ICU 患者比例。次要结果包括死亡率、无生命支持的存活天数、离开重症监护室的存活天数、离开医院的存活天数(均在 90 天内)以及发生一次或多次严重不良事件的患者人数:我们将描述使用促动力药的数据,并使用将死亡和出ICU作为竞争事件的Cox回归来评估患者特征与促动力药使用之间的关系。我们将使用具有时变协变量的扩展 Cox 模型和线性回归模型来评估促动力药的使用与次要结果之间的关联:概述的国际队列研究将提供有关成人急诊 ICU 患者使用促动力药的宝贵流行病学数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
9.50%
发文量
157
审稿时长
3-8 weeks
期刊介绍: Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.
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