A retrospective single-centre study on determinants of high-risk coronary artery calcium (CAC) score in women.

Abstract

One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We conducted analysis on the determinants of high-risk coronary calcification, represented by CAC score, among women as a step to improve their outcomes and prognosis. This study involved a total of 1,129 female patients from a single centre. There were 127 patients (11.2%) classified as high risk (CAC ≥400). We found that a history of hypertension and diabetes are independent determinants of having a high-risk CAC score. Furthermore, this study demonstrated protective effects associated with physical activity and diastolic blood pressure. In conclusion, a history of hypertension, diabetes, and high uncontrolled systolic blood pressure might be used as cues for physicians to prioritise CAC assessment in women, despite the absence of chest pain or atypical symptoms.