Emergence and stability of endoplasmic reticulum network streaming in plant cells

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-27 DOI:10.1016/j.jtbi.2024.111954

Graham M. Donovan , Congping Lin , Imogen Sparkes , Peter Ashwin

引用次数: 0

Abstract

The endoplasmic reticulum (ER) network is highly complex and highly dynamic in its geometry, and undergoes extensive remodeling and bulk flow. It is known that the ER dynamics are driven by actin–myosin dependent processes. ER motion through the cytoplasm will cause forces on the cytoplasm that will induce flow. However, ER will also clearly be passively transported by the bulk cytoplasmic streaming. We take the complex ER network structure into account and propose a positive-feedback mechanism among myosin-like motors, actin alignment, ER network dynamics for the emergence of ER flow. Using this model, we demonstrate that ER streaming may be an emergent feature of this three-way interaction and that the persistent-point density may be a key driver of the emergence of ER streaming.

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植物细胞内质网网络流的出现和稳定性。

内质网（ER）网络的几何结构非常复杂，动态性很强，并经历着广泛的重塑和大量流动。众所周知，内质网的动态是由肌动蛋白驱动的。ER 在细胞质中的运动会对细胞质产生作用力，从而引起流动。然而，ER 显然也会被大量的细胞质流被动地传送。我们将复杂的ER网络结构考虑在内，提出了一种肌球蛋白样马达、肌动蛋白排列和ER网络动力学之间的正反馈机制，以促进ER流动的出现。利用这个模型，我们证明了ER流可能是这种三向相互作用的一个新兴特征，而持久点密度可能是ER流出现的一个关键驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.