Disordered Gut Microbiome and Alterations in Metabolic Patterns Are Associated With Hypertensive Left Ventricular Hypertrophy.

IF 5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Heart Association Pub Date : 2024-10-01 Epub Date: 2024-09-29 DOI:10.1161/JAHA.123.034230

Rong Cao, Ting Gao, Jianwei Yue, Gang Sun, Xiaomin Yang

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引用次数: 0

Abstract

Background: Left ventricular hypertrophy (LVH) is most common when driven by hypertension, and it is a strong independent risk factor for adverse cardiovascular events and death. Some animal models support a role for gut microbiota and metabolites in the development of LVH, but cohort studies confirming these findings in populations are lacking.

Methods and results: We investigated the alterations of gut microbiota and metabolites in 30 patients with hypertension, 30 patients with hypertensive LVH, and 30 matched controls on the basis of 16S rDNA and metabolomic analyses. Thirty stool and 90 serum samples were collected in fasting conditions. ANOVA/Kruskal-Wallis/Pearson's χ²/Fisher's exact test and Bonferroni's correction were used (P<0.0167) for comparison among the 3 groups. A regression analysis and subgroup analysis were performed between gut microbiota and left ventricular mass index (LVMI) and metabolites and LVMI, respectively. Spearman correlation analysis was performed between metabolites and flora and metabolites and LVMI. We observed LVH-enriched Faecalitalea (β=6758.55 [95% CI, 2080.92-11436.18]; P=0.009), Turicibacter (β=8424.76 [95% CI, 2494.05-14355.47]; P=0.01), Ruminococcus torques group (β=840.88 [95% CI, 223.1-1458.67]; P=0.013), and Erysipelotrichaceae UCG-003 (β=856.37 [95% CI, 182.76-1529.98]; P=0.019) were positively correlated with LVMI. A total of 1141 (in sera) and 2657 (in feces) metabolites were identified. There was a sex-specific association between metabolites and LVMI. Significant changes in metabolic pathways in LVH were also observed, especially bile acid and lipid metabolism pathways.

Conclusions: Our study demonstrated the disordered gut microbiota and microbial metabolite profiles in LVH. This highlights the roles of gut bacteria and metabolite in this disease and could lead to new intervention, diagnostic, or management paradigms for LVH.

Registration: URL: https://www.chictr.org.cn; Unique Identifier: ChiCTR2200055603.

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肠道微生物组紊乱和代谢模式改变与高血压左心室肥大有关

背景：左心室肥厚（LVH）在高血压的驱动下最为常见，它是导致不良心血管事件和死亡的一个强有力的独立风险因素。一些动物模型支持肠道微生物群和代谢物在左心室肥厚发病中的作用，但缺乏在人群中证实这些发现的队列研究：我们以 16S rDNA 和代谢组学分析为基础，调查了 30 名高血压患者、30 名高血压左心室积水患者和 30 名匹配对照者的肠道微生物群和代谢物的变化。研究人员在空腹状态下采集了 30 份粪便样本和 90 份血清样本。采用方差分析/Kruskal-Wallis/Pearson's χ2/Fisher's精确检验和Bonferroni校正（PFaecalitalea（β=6758.55 [95% CI, 2080.92-11436.18]; P=0.009）、Turisibacter（β=8424.76 [95% CI, 2494.05-14355.47]；P=0.01）、瘤胃反刍球菌组（β=840.88[95% CI，223.1-1458.67]；P=0.013）和绿脓杆菌 UCG-003（β=856.37[95% CI，182.76-1529.98]；P=0.019）与 LVMI 呈正相关。共鉴定出 1141 种（血清中）和 2657 种（粪便中）代谢物。代谢物与 LVMI 之间存在性别特异性关联。此外，还观察到 LVH 患者的代谢途径发生了显著变化，尤其是胆汁酸和脂质代谢途径：我们的研究表明，左心室肥厚患者的肠道微生物群和微生物代谢物谱紊乱。结论：我们的研究表明，LVH 患者的肠道微生物群和微生物代谢物谱紊乱，这凸显了肠道细菌和代谢物在这种疾病中的作用，并可能为 LVH 带来新的干预、诊断或管理范例：URL: https://www.chictr.org.cn; Unique Identifier：ChiCTR2200055603。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Heart Association CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

9.40

自引率

1.90%

发文量

1749

审稿时长

12 weeks

期刊介绍： As an Open Access journal, JAHA - Journal of the American Heart Association is rapidly and freely available, accelerating the translation of strong science into effective practice. JAHA is an authoritative, peer-reviewed Open Access journal focusing on cardiovascular and cerebrovascular disease. JAHA provides a global forum for basic and clinical research and timely reviews on cardiovascular disease and stroke. As an Open Access journal, its content is free on publication to read, download, and share, accelerating the translation of strong science into effective practice.