Levels and functionality of Pacific Islanders' hybrid humoral immune response to BNT162b2 vaccination and delta/omicron infection: A cohort study in New Caledonia.

IF 15.8 1区医学 Q1 Medicine

PLoS Medicine Pub Date : 2024-09-26 eCollection Date: 2024-09-01 DOI:10.1371/journal.pmed.1004397

Catherine Inizan, Adrien Courtot, Chloé Sturmach, Anne-Fleur Griffon, Antoine Biron, Timothée Bruel, Vincent Enouf, Thibaut Demaneuf, Sandie Munier, Olivier Schwartz, Ann-Claire Gourinat, Georges Médevielle, Marc Jouan, Sylvie van der Werf, Yoann Madec, Valérie Albert-Dunais, Myrielle Dupont-Rouzeyrol

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引用次数: 0

Abstract

Background: Pacific Islanders are underrepresented in vaccine efficacy trials. Few studies describe their immune response to COVID-19 vaccination. Yet, this characterization is crucial to re-enforce vaccination strategies adapted to Pacific Islanders singularities.

Methods and findings: We evaluated the humoral immune response of 585 adults, self-declaring as Melanesians, Europeans, Polynesians, or belonging to other communities, to the Pfizer BNT162b2 vaccine. Anti-spike and anti-nucleoprotein IgG levels, and their capacity to neutralize SARS-CoV-2 variants and to mediate antibody-dependent cellular cytotoxicity (ADCC) were assessed across communities at 1 and 3 months post-second dose or 1 and 6 months post-third dose. All sera tested contained anti-spike antibodies and 61.3% contained anti-nucleoprotein antibodies, evidencing mostly a hybrid immunity resulting from vaccination and SARS-CoV-2 infection. At 1-month post-immunization, the 4 ethnic communities exhibited no significant differences in their anti-spike IgG levels (p value = 0.17, in an univariate linear regression model), in their capacity to mediate omicron neutralization (p value = 0.59 and 0.60, in an univariate logistic regression model at 1-month after the second and third dose, respectively) and in their capacity to mediate ADCC (p value = 0.069 in a multivariate linear regression model), regardless of the infection status. Anti-spike IgG levels and functionalities of the hybrid humoral immune response remained equivalent across the 4 ethnic communities during follow-up and at 6 months post-third dose.

Conclusions: Our study evidenced Pacific Islander's robust humoral immune response to Pfizer BNT162b2 vaccine, which is pivotal to re-enforce vaccination deployment in a population at risk for severe COVID-19.

Trial registration: This trial has been register in ClinicalTrials.gov (ID: NCT05135585).

查看原文本刊更多论文

太平洋岛民对 BNT162b2 疫苗接种和 delta/omicron 感染的混合体液免疫反应的水平和功能：新喀里多尼亚队列研究。

背景：太平洋岛民在疫苗效力试验中的代表性不足。很少有研究描述他们对接种 COVID-19 疫苗的免疫反应。然而，这一特征对于加强适应太平洋岛民特殊性的疫苗接种策略至关重要：我们评估了 585 名自称为美拉尼西亚人、欧洲人、波利尼西亚人或属于其他社区的成年人对辉瑞 BNT162b2 疫苗的体液免疫反应。在接种第二剂疫苗后的 1 个月和 3 个月，或接种第三剂疫苗后的 1 个月和 6 个月，对各群体的抗尖峰抗体和抗核蛋白 IgG 水平及其中和 SARS-CoV-2 变体和介导抗体依赖性细胞毒性（ADCC）的能力进行了评估。所有检测的血清中都含有抗尖峰抗体，61.3%的血清中含有抗核蛋白抗体，这主要证明了疫苗接种和 SARS-CoV-2 感染所产生的混合免疫力。在免疫后 1 个月，4 个种族社区的抗尖峰抗体 IgG 水平（单变量线性回归模型中的 p 值 = 0.17）、介导 omicron 中和的能力（单变量线性回归模型中的 p 值 = 0.59和0.60），以及它们介导ADCC的能力（多变量线性回归模型中p值=0.069），与感染状态无关。在随访期间和第三剂后 6 个月，4 个族裔社区的抗尖峰蛋白 IgG 水平和混合体液免疫反应的功能仍然相同：我们的研究证明了太平洋岛民对辉瑞 BNT162b2 疫苗的强大体液免疫反应，这对于在有严重 COVID-19 风险的人群中加强疫苗接种部署至关重要（clinicaltrials.gov：NCT05135585）：该试验已在 ClinicalTrials.gov 注册（ID：NCT05135585）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

17.60

自引率

0.60%

发文量

227

审稿时长

4-8 weeks

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