Metabolic syndrome and patient-reported outcome two years after hip and knee arthroplasty.

IF 4.9 1区医学 Q1 ORTHOPEDICS

Bone & Joint Journal Pub Date : 2024-10-01 DOI:10.1302/0301-620X.106B10.BJJ-2024-0087.R1

Rasmus R Sørensen, Signe Timm, Lasse E Rasmussen, Claus L Brasen, Claus Varnum

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引用次数: 0

Abstract

Aims: The influence of metabolic syndrome (MetS) on the outcome after hip and knee arthroplasty is debated. We aimed to investigate the change in patient-reported outcome measure (PROM) scores after hip and knee arthroplasty, comparing patients with and without MetS.

Methods: From 1 May 2017 to 30 November 2019, a prospective cohort of 2,586 patients undergoing elective unilateral hip and knee arthroplasty was established in Denmark. Data from national registries and a local database were used to determine the presence of MetS. Patients' scores on Oxford Hip Score (OHS) or Oxford Knee Score (OKS), EuroQol five-dimension five-level questionnaire (EQ-5D-5L), University of California, Los Angeles (UCLA) Activity Scale, and Forgotten Joint Score (FJS) at baseline, three, 12, and 24 months after surgery were collected. Primary outcome was the difference between groups from baseline to 12 months in OHS and OKS. Secondary outcomes were scores of OHS and OKS at three and 24 months and EQ-5D-5L, UCLA Activity Scale, and FJS at three, 12, and 24 months after surgery. Generalized linear mixed model was applied, adjusting for age, sex, Charlson Comorbidity Index, and smoking to present marginal mean and associated 95% CIs.

Results: A total of 62.3% (1,611/2,586) of the cohort met the criteria for MetS. Both groups showed similar increase in mean OHS (MetS group 22.5 (95% CI 21.8 to 23.1), non-MetS group 22.1 (21.3 to 22.8); p = 0.477) and mean OKS (MetS group 18.0 (17.4 to 18.6), non-MetS group 17.8 (17.0 to 18.7); p = 0.722) at 12 months' follow-up. Between groups, similar improvements were seen for OHS and OKS at three and 24 months postoperatively and for the mean EQ-5D-5L, EuroQol-visual analogue scale (EQ-VAS), UCLA Activity Scale, and FJS at every timepoint.

Conclusion: Patients meeting the criteria for MetS obtain the same improvement in PROM scores as individuals without MetS up to 24 months after hip and knee arthroplasty. This is important for the clinician to take into account when assessing and advising patients with MetS.

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代谢综合征与髋关节和膝关节置换术后两年的患者报告结果。

目的：代谢综合征（MetS）对髋关节和膝关节置换术后预后的影响尚存在争议。我们旨在研究髋关节和膝关节置换术后患者报告结果测量（PROM）评分的变化，并对患有和不患有 MetS 的患者进行比较：从 2017 年 5 月 1 日至 2019 年 11 月 30 日，在丹麦建立了一个前瞻性队列，包含 2586 名接受择期单侧髋关节和膝关节置换术的患者。国家登记处和当地数据库的数据用于确定是否存在 MetS。收集了患者在基线、术后3个月、12个月和24个月时的牛津髋关节评分（OHS）或牛津膝关节评分（OKS）、EuroQol五维五级问卷（EQ-5D-5L）、加州大学洛杉矶分校（UCLA）活动量表和遗忘关节评分（FJS）。主要结果是各组间从基线到 12 个月的 OHS 和 OKS 差异。次要结果是术后 3 个月、24 个月时的 OHS 和 OKS 分数，以及术后 3 个月、12 个月和 24 个月时的 EQ-5D-5L、UCLA 活动量表和 FJS 分数。应用广义线性混合模型，对年龄、性别、查尔森综合征指数和吸烟进行调整，得出边际平均值和相关的 95% CIs：共有 62.3%（1,611/2,586）的患者符合 MetS 标准。在随访 12 个月时，两组的平均 OHS（MetS 组 22.5（95% CI 21.8 至 23.1），非 MetS 组 22.1（21.3 至 22.8）；p = 0.477）和平均 OKS（MetS 组 18.0（17.4 至 18.6），非 MetS 组 17.8（17.0 至 18.7）；p = 0.722）均有相似的增长。在各组之间，术后 3 个月和 24 个月的 OHS 和 OKS 以及每个时间点的平均 EQ-5D-5L、EQ-VAS、UCLA 活动量表和 FJS 均有相似的改善：结论：在髋关节和膝关节置换术后24个月内，符合MetS标准的患者与非MetS患者的PROM评分获得了相同的改善。临床医生在评估和指导 MetS 患者时应考虑到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bone & Joint Journal ORTHOPEDICS-SURGERY

CiteScore

9.40

自引率

10.90%

发文量

318

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